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10.1097/00005344-199509000-00008 http://scihub22266oqcxt.onion/10.1097/00005344-199509000-00008 8583780!ä!8583780 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cardiovasc+Pharmacol 1995 ; 26 (3): 394-400 Nephropedia Template TP {{tp|p=8583780|t=1995. Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure |pdf=|usr=}}{{8583780}} gab.com Text Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure JO: J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=8583780 #FOAvip In the absence of formal clinical trials, the efficacy of thiazide diuretics in patients with renal impairment remains in doubt. Our study was therefore designed to evaluate the separate and combined effects of single and multiple doses of hydrochlorothiazide (HCTZ) and furosemide (FU) on the glomerular filtration rate (GFR) and electrolyte excretion in 19 patients with chronic renal insufficiency and in six normal control subjects by a randomized single-blind protocol. After establishment of a steady state of urinary electrolyte excretion, a single oral dose of HCTZ (25 mg) induced increases in the urinary excretion of Na+, K+, Cl-, Ca2+, and Mg2+ over the subsequent 12 h, which was significantly inversely related to the GFR for each electrolyte. The ratios of HCTZ-induced excretion of the different electrolytes were constant and independent of the GFR. After HCTZ, there was a double peak of Na+ excretion related to the abrupt reduction in GFR and Na+ excretion when the latter exceeded 40 mmol/h in normal subjects and 15 mmol/h in patients with advanced renal failure. The dose-response curves for HCTZ and FU were both relatively flat: doubling the dose of each produced statistically insignificant increases in sodium excretion. In contrast, when the lower doses of each were coadministered, there was a substantial and statistically significant increase in Na+ excretion. The clinical implication of these findings is that a combination of low doses of diuretics acting at different functional sites of electrolyte reabsorption in the nephron is superior in saluretic potency to increasing the dose of either diuretic alone. Twit Text FOAVip Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure ????J Cardiovasc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=8583780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8583780 #FOAvip English Wikipedia <ref>{{Cite pmid|8583780}}</ref> Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure #MMPMID8583780 Knauf H; Mutschler E J Cardiovasc Pharmacol 1995[Sep]; 26 (3): 394-400 PMID8583780show ga In the absence of formal clinical trials, the efficacy of thiazide diuretics in patients with renal impairment remains in doubt. Our study was therefore designed to evaluate the separate and combined effects of single and multiple doses of hydrochlorothiazide (HCTZ) and furosemide (FU) on the glomerular filtration rate (GFR) and electrolyte excretion in 19 patients with chronic renal insufficiency and in six normal control subjects by a randomized single-blind protocol. After establishment of a steady state of urinary electrolyte excretion, a single oral dose of HCTZ (25 mg) induced increases in the urinary excretion of Na+, K+, Cl-, Ca2+, and Mg2+ over the subsequent 12 h, which was significantly inversely related to the GFR for each electrolyte. The ratios of HCTZ-induced excretion of the different electrolytes were constant and independent of the GFR. After HCTZ, there was a double peak of Na+ excretion related to the abrupt reduction in GFR and Na+ excretion when the latter exceeded 40 mmol/h in normal subjects and 15 mmol/h in patients with advanced renal failure. The dose-response curves for HCTZ and FU were both relatively flat: doubling the dose of each produced statistically insignificant increases in sodium excretion. In contrast, when the lower doses of each were coadministered, there was a substantial and statistically significant increase in Na+ excretion. The clinical implication of these findings is that a combination of low doses of diuretics acting at different functional sites of electrolyte reabsorption in the nephron is superior in saluretic potency to increasing the dose of either diuretic alone. |Adult[MESH] |Aged[MESH] |Calcium/urine[MESH] |Chlorides/urine[MESH] |Diuretics/administration & dosage/pharmacology/*therapeutic use[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Synergism[MESH] |Electrolytes/metabolism[MESH] |Female[MESH] |Furosemide/administration & dosage/pharmacology/*therapeutic use[MESH] |Glomerular Filtration Rate/*drug effects[MESH] |Humans[MESH] |Hydrochlorothiazide/administration & dosage/pharmacology/*therapeutic use[MESH] |Kidney Failure, Chronic/*drug therapy[MESH] |Magnesium/urine[MESH] |Male[MESH] |Middle Aged[MESH] |Potassium/urine[MESH]Diuretic effectiveness of hydrochlorothiazide and furosemide alone and(epmc).pdf DeepDyve Pubget Overpricing