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10.1002/jlb.59.1.61 http://scihub22266oqcxt.onion/10.1002/jlb.59.1.61 8558069!ä!8558069 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Leukoc+Biol 1996 ; 59 (1): 61-6 Nephropedia Template TP {{tp|p=8558069|t=1996. The role of MIP-1 alpha in inflammation and hematopoiesis |pdf=|usr=}}{{8558069}} gab.com Text The role of MIP-1 alpha in inflammation and hematopoiesis JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=8558069 #FOAvip Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis. MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo. Here, the biologic properties of MIP-1 alpha are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1 alpha is not necessary for normal hematopoiesis. However, the MIP-1 alpha null mice have a mice have a reduced inflammatory reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis. These data demonstrate that MIP-1 alpha is required for a normal inflammatory response to these viruses. Agent that inhibit the action of MIP-1 alpha may therefore prove useful for controlling inflammation in these and other settings. Twit Text FOAVip The role of MIP-1 alpha in inflammation and hematopoiesis ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=8558069 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8558069 #FOAvip English Wikipedia <ref>{{Cite pmid|8558069}}</ref> The role of MIP-1 alpha in inflammation and hematopoiesis #MMPMID8558069 Cook DN J Leukoc Biol 1996[Jan]; 59 (1): 61-6 PMID8558069show ga Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of the C-C subfamily of chemokines, a large superfamily of low-molecular weight, inducible proteins that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis. MIP-1 alpha is a particularly interesting chemokine, because in addition to its proinflammatory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo. Here, the biologic properties of MIP-1 alpha are reviewed in light of recent data on mice homozygous for a disruption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no overt abnormalities of peripheral blood or bone marrow cells, indicating that MIP-1 alpha is not necessary for normal hematopoiesis. However, the MIP-1 alpha null mice have a mice have a reduced inflammatory reduced inflammatory response to influenza virus and are resistant to coxsackievirus-induced myocarditis. These data demonstrate that MIP-1 alpha is required for a normal inflammatory response to these viruses. Agent that inhibit the action of MIP-1 alpha may therefore prove useful for controlling inflammation in these and other settings. |Animals[MESH] |Chemokine CCL3[MESH] |Chemokine CCL4[MESH] |Hematopoiesis/*physiology[MESH] |Humans[MESH] |Inflammation/*physiopathology[MESH] |Macrophage Inflammatory Proteins[MESH] |Mice[MESH]The role of MIP-1 alpha in inflammation and hematopoiesis (epmc).pdf DeepDyve Pubget Overpricing