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10.1097/00006565-199302000-00008

http://scihub22266oqcxt.onion/10.1097/00006565-199302000-00008
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8488140!ä!8488140

suck abstract from ncbi


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pmid8488140      Pediatr+Emerg+Care 1993 ; 9 (1): 23-5
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  • Torsade de pointes associated with Astemizole overdose treated with magnesium sulfate #MMPMID8488140
  • Hasan RA; Zureikat GY; Nolan BM
  • Pediatr Emerg Care 1993[Feb]; 9 (1): 23-5 PMID8488140show ga
  • Astemizole (Hismanal-Janssen, New Brunswick, NJ) is a nonsedating antihistamine that has the advantage of a once-daily dosage schedule. This article reports the case of a 14-year-old female who intentionally ingested 270 mg of Astemizole and developed torsade de pointes, a form of polymorphic ventricular tachycardia that is associated with prolongation of the QTc interval. She was successfully treated with magnesium sulfate infusion and had an uneventful recovery over a period of 36 hours. This case illustrates that Astemizole overdose is not benign and should be considered in the differential diagnosis of ventricular tachyarrhythmias. Use of high-dose Astemizole may not be advisable for patients who are at risk for prolongation of the QTc interval.
  • |Adolescent[MESH]
  • |Astemizole/*poisoning[MESH]
  • |Drug Overdose[MESH]
  • |Electrocardiography[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Magnesium Sulfate/*therapeutic use[MESH]
  • |Poisoning/drug therapy[MESH]


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