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10.1213/00000539-199305000-00033 http://scihub22266oqcxt.onion/10.1213/00000539-199305000-00033 8484515!ä!8484515 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anesth+Analg 1993 ; 76 (5): 1106-13 Nephropedia Template TP {{tp|p=8484515|t=1993. Halothane inhibits the intraalveolar recruitment of neutrophils, lymphocytes, and macrophages in response to influenza virus infection in mice |pdf=|usr=}}{{8484515}} gab.com Text Halothane inhibits the intraalveolar recruitment of neutrophils, lymphocytes, and macrophages in response to influenza virus infection in mice JO: Anesth Analg http://www.kidney.de/pget.php?&tw=1&pmid=8484515 #FOAvip The effect of halothane anesthesia on the influenza A specific immune response and the pathogenesis of infection was evaluated in mice. Three-wk-old CD-1 mice were anesthetized with either 2% halothane for 2 h or ketamine (100 mg/kg intraperitoneally) and subsequently inoculated intranasally with a sublethal dose of influenza type A/PR/8/34 virus. Bronchoalveolar lavage was performed on animals from each group at 4 h postinoculation and daily thereafter for 14 days. Total and differential white blood cell counts were measured in the lavage fluid and the lungs were examined histologically for evidence of injury. Infected mice anesthetized with halothane had lower daily cell counts in the lung than animals anesthetized with ketamine and a marked change in cell type distribution. On Days 4 and 11 postinoculation, there were significantly (P < 0.05) more white blood cells in the lavage fluid of animals anesthetized with ketamine than halothane (mean/mL, 738,000 +/- SEM, 128,000 vs 196,000 +/- 51,400, respectively, and 1,020,000 +/- 227,000 vs 117,000 +/- 34,600, respectively). Differential counts were significantly higher (P < 0.05) in the ketamine group compared to the halothane for neutrophils on Day 4 (452,000 +/- 77,900 vs 72,000 +/- 46,000, respectively) and on Day 11 for lymphocytes (340,000 +/- 59,000 vs 33,000 +/- 17,000, respectively) and macrophages (480,000 +/- 120,000 vs 130,000 +/- 61,000). Infected mice that were given ketamine were qualitatively "sicker" than the halothane-treated group as evidenced by the appearance of ruffled fur, tachypnea, and cachexia. Animals anesthetized with ketamine demonstrated a greater degree of pulmonary histopathology including diffuse infiltration of macrophages, neutrophils, hemorrhage, and fibrin deposition.(ABSTRACT TRUNCATED AT 250 WORDS) Twit Text FOAVip Halothane inhibits the intraalveolar recruitment of neutrophils, lymphocytes, and macrophages in response to influenza virus infection in mice ????Anesth Analg http://www.kidney.de/pget.php?&tw=1&pmid=8484515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8484515 #FOAvip English Wikipedia <ref>{{Cite pmid|8484515}}</ref> Halothane inhibits the intraalveolar recruitment of neutrophils, lymphocytes, and macrophages in response to influenza virus infection in mice #MMPMID8484515 Tait AR; Davidson BA; Johnson KJ; Remick DG; Knight PR Anesth Analg 1993[May]; 76 (5): 1106-13 PMID8484515show ga The effect of halothane anesthesia on the influenza A specific immune response and the pathogenesis of infection was evaluated in mice. Three-wk-old CD-1 mice were anesthetized with either 2% halothane for 2 h or ketamine (100 mg/kg intraperitoneally) and subsequently inoculated intranasally with a sublethal dose of influenza type A/PR/8/34 virus. Bronchoalveolar lavage was performed on animals from each group at 4 h postinoculation and daily thereafter for 14 days. Total and differential white blood cell counts were measured in the lavage fluid and the lungs were examined histologically for evidence of injury. Infected mice anesthetized with halothane had lower daily cell counts in the lung than animals anesthetized with ketamine and a marked change in cell type distribution. On Days 4 and 11 postinoculation, there were significantly (P < 0.05) more white blood cells in the lavage fluid of animals anesthetized with ketamine than halothane (mean/mL, 738,000 +/- SEM, 128,000 vs 196,000 +/- 51,400, respectively, and 1,020,000 +/- 227,000 vs 117,000 +/- 34,600, respectively). Differential counts were significantly higher (P < 0.05) in the ketamine group compared to the halothane for neutrophils on Day 4 (452,000 +/- 77,900 vs 72,000 +/- 46,000, respectively) and on Day 11 for lymphocytes (340,000 +/- 59,000 vs 33,000 +/- 17,000, respectively) and macrophages (480,000 +/- 120,000 vs 130,000 +/- 61,000). Infected mice that were given ketamine were qualitatively "sicker" than the halothane-treated group as evidenced by the appearance of ruffled fur, tachypnea, and cachexia. Animals anesthetized with ketamine demonstrated a greater degree of pulmonary histopathology including diffuse infiltration of macrophages, neutrophils, hemorrhage, and fibrin deposition.(ABSTRACT TRUNCATED AT 250 WORDS) |*Influenza A virus[MESH] |Animals[MESH] |Bronchoalveolar Lavage Fluid/cytology[MESH] |Halothane/*pharmacology[MESH] |Ketamine/pharmacology[MESH] |Leukocyte Count[MESH] |Macrophages, Alveolar[MESH] |Male[MESH] |Mice[MESH] |Neutrophils[MESH] |Orthomyxoviridae Infections/*immunology/pathology[MESH] |Pulmonary Alveoli/drug effects/*microbiology[MESH]Halothane inhibits the intraalveolar recruitment of neutrophils, lymph(epmc).pdf DeepDyve Pubget Overpricing