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10.1016/0016-5085(93)90361-f http://scihub22266oqcxt.onion/10.1016/0016-5085(93)90361-f 8482461!?!8482461 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=8482461&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Gastroenterology 1993 ; 104 (5): 1492-7 Nephropedia Template TP {{tp|p=8482461|t=1993. Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients |pdf=|usr=}}{{8482461}} gab.com Text Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients JO: Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=8482461 #FOAvip BACKGROUND: Patients with liver cirrhosis disclose both increased production and decreased metabolism of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6). The present study analyzes the characteristic pattern of these cytokines during sepsis in cirrhotics. METHODS: TNF-alpha and IL-6 plasma levels, measured during 15 days from the onset of cirrhotic decompensation or of the septic event, were compared between 14 infected patients with liver cirrhosis, 18 uninfected decompensated cirrhotic patients, and 35 septicemic patients devoid of liver disease. Cytokines were measured using immunoassays. RESULTS: In infected cirrhotics, initial levels of both TNF-alpha and IL-6 were significantly higher than in noninfected cirrhotic patients (P < 0.0001) or in septicemic patients devoid of cirrhosis (P < 0.001). Initial IL-6 plasma levels (threshold, 200 pg/mL) showed 89% specificity and 100% sensitivity in discriminating cirrhotic decompensation due to infection from that caused by other factors. TNF-alpha and IL-6 plasma levels remained significantly higher for many days in infected cirrhotic patients compared with the other two groups. CONCLUSIONS: Both the profoundly increased initial levels of TNF-alpha and IL-6 and their persistence over days after sepsis onset seem characteristic of the cirrhotic patients. The exact relationship between prolonged exposure to TNF-alpha and poor prognosis in these patients is unknown, but it might represent a unique opportunity for the use of anti-TNF-alpha antibodies during sepsis. Twit Text FOAVip Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients ????Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=8482461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8482461 #FOAvip English Wikipedia <ref>{{Cite pmid|8482461}}</ref> Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients #MMPMID8482461 Byl B; Roucloux I; Crusiaux A; Dupont E; Deviere J Gastroenterology 1993[May]; 104 (5): 1492-7 PMID8482461show ga BACKGROUND: Patients with liver cirrhosis disclose both increased production and decreased metabolism of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6). The present study analyzes the characteristic pattern of these cytokines during sepsis in cirrhotics. METHODS: TNF-alpha and IL-6 plasma levels, measured during 15 days from the onset of cirrhotic decompensation or of the septic event, were compared between 14 infected patients with liver cirrhosis, 18 uninfected decompensated cirrhotic patients, and 35 septicemic patients devoid of liver disease. Cytokines were measured using immunoassays. RESULTS: In infected cirrhotics, initial levels of both TNF-alpha and IL-6 were significantly higher than in noninfected cirrhotic patients (P < 0.0001) or in septicemic patients devoid of cirrhosis (P < 0.001). Initial IL-6 plasma levels (threshold, 200 pg/mL) showed 89% specificity and 100% sensitivity in discriminating cirrhotic decompensation due to infection from that caused by other factors. TNF-alpha and IL-6 plasma levels remained significantly higher for many days in infected cirrhotic patients compared with the other two groups. CONCLUSIONS: Both the profoundly increased initial levels of TNF-alpha and IL-6 and their persistence over days after sepsis onset seem characteristic of the cirrhotic patients. The exact relationship between prolonged exposure to TNF-alpha and poor prognosis in these patients is unknown, but it might represent a unique opportunity for the use of anti-TNF-alpha antibodies during sepsis. |Aged[MESH] |Bacterial Infections/blood/*complications/diagnosis[MESH] |Humans[MESH] |Interleukin-6/*blood[MESH] |Liver Cirrhosis/*blood/complications[MESH] |Middle Aged[MESH] |Sensitivity and Specificity[MESH] |Time Factors[MESH]Tumor necrosis factor alpha and interleukin 6 plasma levels in infecte(epmc).pdf DeepDyve Pubget Overpricing