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10.1073/pnas.90.7.2749 http://scihub22266oqcxt.onion/10.1073/pnas.90.7.2749 8464884!46173!8464884     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 1993 ; 90 (7): 2749-53 Nephropedia Template TP {{tp|p=8464884|t=1993. Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter |pdf=|usr=}}{{8464884}} gab.com Text Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=8464884 #FOAvip Electroneutral Na+:Cl- cotransport systems are involved in a number of important physiological processes including salt absorption and secretion by epithelia and cell volume regulation. One group of Na+:Cl- cotransporters is specifically inhibited by the benzothiadiazine (thiazide) class of diuretic agents and can be distinguished from Na+:K+:2Cl- cotransporters based on a lack of K+ requirement and insensitivity to sulfamoylbenzoic acid diruetics like bumetanide. We report here the isolation of a cDNA encoding a thiazide-sensitive, electroneutral sodium-chloride cotransporter from the winter flounder urinary bladder using an expression cloning strategy. The pharmacological and kinetic characteristics of the cloned cotransporter are consistent with the properties of native thiazide-sensitive sodium-chloride cotransporters in teleost urinary bladder and mammalian renal distal tubule epithelia. The nucleotide sequence predicts a protein of 1023 amino acids (112 kDa) with 12 putative membrane-spanning regions, which is not related to other previously cloned sodium or chloride transporters. Northern hybridization shows two different gene products: a 3.7-kb mRNA localized only to the urinary bladder and a 3.0-kb mRNA present in several non-bladder/kidney tissues. Twit Text FOAVip Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=8464884 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8464884 #FOAvip English Wikipedia <ref>{{Cite pmid|8464884}}</ref> Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter #MMPMID8464884 Gamba G; Saltzberg SN; Lombardi M; Miyanoshita A; Lytton J; Hediger MA; Brenner BM; Hebert SC Proc Natl Acad Sci U S A 1993[Apr]; 90 (7): 2749-53 PMID8464884show ga Electroneutral Na+:Cl- cotransport systems are involved in a number of important physiological processes including salt absorption and secretion by epithelia and cell volume regulation. One group of Na+:Cl- cotransporters is specifically inhibited by the benzothiadiazine (thiazide) class of diuretic agents and can be distinguished from Na+:K+:2Cl- cotransporters based on a lack of K+ requirement and insensitivity to sulfamoylbenzoic acid diruetics like bumetanide. We report here the isolation of a cDNA encoding a thiazide-sensitive, electroneutral sodium-chloride cotransporter from the winter flounder urinary bladder using an expression cloning strategy. The pharmacological and kinetic characteristics of the cloned cotransporter are consistent with the properties of native thiazide-sensitive sodium-chloride cotransporters in teleost urinary bladder and mammalian renal distal tubule epithelia. The nucleotide sequence predicts a protein of 1023 amino acids (112 kDa) with 12 putative membrane-spanning regions, which is not related to other previously cloned sodium or chloride transporters. Northern hybridization shows two different gene products: a 3.7-kb mRNA localized only to the urinary bladder and a 3.0-kb mRNA present in several non-bladder/kidney tissues. |*Symporters[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Base Sequence[MESH] |Benzothiadiazines/*pharmacology[MESH] |Carrier Proteins/drug effects/*genetics/*physiology[MESH] |DNA/*genetics/isolation & purification[MESH] |Flounder[MESH] |Intestines/physiology[MESH] |Kinetics[MESH] |Models, Structural[MESH] |Molecular Sequence Data[MESH] |Oocytes/drug effects/*physiology[MESH] |Open Reading Frames[MESH] |Organ Specificity[MESH] |Protein Structure, Secondary[MESH] |Recombinant Proteins/drug effects/metabolism[MESH] |Sodium Chloride Symporters[MESH] |Sodium/*metabolism[MESH] |Urinary Bladder/*physiology[MESH]Primary structure and functional expression of a cDNA encoding the th(epmc).pdf DeepDyve Pubget Overpricing