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10.1152/ajpcell.1993.264.3.C723 http://scihub22266oqcxt.onion/10.1152/ajpcell.1993.264.3.C723 8460675!ä!8460675 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol 1993 ; 264 (3 Pt 1): C723-6 Nephropedia Template TP {{tp|p=8460675|t=1993. Modulation of cytokines and myocardial lesions by vitamin E and chloroquine in a Mg-deficient rat model |pdf=|usr=}}{{8460675}} gab.com Text Modulation of cytokines and myocardial lesions by vitamin E and chloroquine in a Mg-deficient rat model JO: Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=8460675 #FOAvip Antioxidant treatment with alpha-tocopherol did not affect the level of the "inflammatory cytokines" in Mg-deficient animals, although it diminished the extent of the myocardial lesions. In another group of Mg-deficient animals chloroquine treatment diminished significantly the levels of circulating cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and also resulted in a major decrease in myocardial lesions. These results raise the question of the role of these inflammatory cytokines in the formation of lesions in Mg-deficient myocardium. Because these cytokines are able to stimulate free radical production in various cell types, we postulate that Mg deficiency involves free radical mechanisms that can be amplified by inflammatory cytokines; whether these cytokines initiate lesion formation is unclear. Although our data do not confirm either possibility, we submit that these results implicate a role for the inflammatory cytokines in the cardiac pathology of Mg deficiency. Twit Text FOAVip Modulation of cytokines and myocardial lesions by vitamin E and chloroquine in a Mg-deficient rat model ????Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=8460675 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8460675 #FOAvip English Wikipedia <ref>{{Cite pmid|8460675}}</ref> Modulation of cytokines and myocardial lesions by vitamin E and chloroquine in a Mg-deficient rat model #MMPMID8460675 Weglicki WB; Stafford RE; Freedman AM; Cassidy MM; Phillips TM Am J Physiol 1993[Mar]; 264 (3 Pt 1): C723-6 PMID8460675show ga Antioxidant treatment with alpha-tocopherol did not affect the level of the "inflammatory cytokines" in Mg-deficient animals, although it diminished the extent of the myocardial lesions. In another group of Mg-deficient animals chloroquine treatment diminished significantly the levels of circulating cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and also resulted in a major decrease in myocardial lesions. These results raise the question of the role of these inflammatory cytokines in the formation of lesions in Mg-deficient myocardium. Because these cytokines are able to stimulate free radical production in various cell types, we postulate that Mg deficiency involves free radical mechanisms that can be amplified by inflammatory cytokines; whether these cytokines initiate lesion formation is unclear. Although our data do not confirm either possibility, we submit that these results implicate a role for the inflammatory cytokines in the cardiac pathology of Mg deficiency. |Animals[MESH] |Cardiomyopathies/*pathology[MESH] |Chloroquine/*pharmacology[MESH] |Cytokines/blood/genetics/*metabolism[MESH] |Disease Models, Animal[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Interleukin-1/blood[MESH] |Interleukin-6/blood[MESH] |Magnesium Deficiency/*metabolism/*pathology[MESH] |Male[MESH] |Myocardium/chemistry/pathology[MESH] |RNA, Messenger/analysis/genetics[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Tumor Necrosis Factor-alpha/analysis[MESH]Modulation of cytokines and myocardial lesions by vitamin E and chloro(epmc).pdf DeepDyve Pubget Overpricing