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pmid8393394
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  • Retroviral interference with neuronotrophic signaling in human motor neuron disease? #MMPMID8393394
  • Westarp ME; Westphal KP; Clausen J; Rasmussen HB; Hoff-Jorgensen R; Fohring B; Kornhuber HH
  • Clin Physiol Biochem 1993[]; 10 (1): 1-7 PMID8393394garesp_yesshow ga
  • We tested 13/32 patients with non-familial amyotrophic lateral sclerosis (ALS) positive (41%) for human spuma retrovirus (HSRV) seroreactivity. Half the non-ALS HSRV-positive neurologic patients (12/25) reported multiple fasciculations within the last two years. Sera from four HSRV-env negative ALS patients measurably competed with visna antibodies on maedi-visna antigen. The serologies for bovine leukemia virus, Borna disease virus and GM1IgM-antibodies remained negative. Both visna and foamy virus sequences share epitopes with motor nervous system signal polypeptides, suggesting a retroviral interference with motor neurono-axonal function and neuronotrophic signals.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Amino Acid Sequence[MESH]
  • |Amyotrophic Lateral Sclerosis/*etiology/immunology[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Molecular Sequence Data[MESH]
  • |Nerve Growth Factors/*immunology[MESH]
  • |Nerve Tissue Proteins/*immunology[MESH]
  • |Protein Sorting Signals/immunology[MESH]
  • |Retroviridae Infections/*complications/immunology[MESH]
  • |Retroviridae Proteins/immunology[MESH]
  • |Spumavirus/*immunology[MESH]


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    1 1.10 1993