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10.1016/0165-5728(93)90160-z

http://scihub22266oqcxt.onion/10.1016/0165-5728(93)90160-z
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8331163!ä!8331163

suck abstract from ncbi


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pmid8331163      J+Neuroimmunol 1993 ; 45 (1-2): 31-6
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  • Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats #MMPMID8331163
  • Sierra-Honigmann AM; Rubin SA; Estafanous MG; Yolken RH; Carbone KM
  • J Neuroimmunol 1993[Jun]; 45 (1-2): 31-6 PMID8331163show ga
  • Borna disease virus (BDV) establishes a persistent infection in cells of the nervous system in rats. The response, or lack thereof, of the immune system to BDV infection of neurons is responsible for the presence or absence, respectively, of Borna disease. We recently demonstrated transmission of BDV by bone marrow cells from neonatally infected rats. Our findings suggested the possibility of a heretofore unsuspected interaction between BDV and the immune system, that of direct effects of BDV infection on the cells of the immune system. This report enlarges upon the previous findings and confirms the presence of BDV RNA in bone marrow cells of neonatally infected rats, using a reverse transcription-polymerization chain reaction-enzyme immunosorbent assay (RT-PCR-EIA). In addition, we detected BDV RNA in peripheral blood mononuclear cells of neonatally infected rats, and in rats inoculated as adults in the chronic, but not the acute, stage of infection. In addition, the RT-PCR-EIA technique identified BDV RNA in cerebrospinal fluid, nasal secretions, saliva, urine and stool. BDV-sequences were not detected in the plasma of infected animals nor in the body fluids and tissues of normal rats.
  • |Aging[MESH]
  • |Animals[MESH]
  • |Animals, Newborn[MESH]
  • |Base Sequence[MESH]
  • |Bone Marrow/*microbiology/pathology[MESH]
  • |Borna Disease/*microbiology/pathology[MESH]
  • |Borna disease virus/*isolation & purification[MESH]
  • |Chronic Disease[MESH]
  • |Immunoenzyme Techniques[MESH]
  • |Molecular Probes/genetics[MESH]
  • |Molecular Sequence Data[MESH]
  • |Monocytes/*microbiology[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]


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