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10.1097/00000658-199312000-00002

http://scihub22266oqcxt.onion/10.1097/00000658-199312000-00002
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suck abstract from ncbi


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pmid8257219      Ann+Surg 1993 ; 218 (6): 705-12
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  • Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma #MMPMID8257219
  • Gadd MA; Casper ES; Woodruff JM; McCormack PM; Brennan MF
  • Ann Surg 1993[Dec]; 218 (6): 705-12 PMID8257219show ga
  • OBJECTIVE: The authors reviewed a series of adult patients with extremity soft tissue sarcoma to determine the incidence of pulmonary metastases and outcome after treatment. METHODS: Of 716 patients admitted between January 1983 and December 1990, 135 (19%) had isolated pulmonary metastases as the initial site of distant recurrence. Fifty-eight percent (78 of 135) of the patients were treated surgically, and 83% of them had their tumors completely resected. RESULTS: The median survival after complete resection was 19 months; incomplete resection, 10 months; and no operation, 8 months (p = 0.005). The 3-year survival rate after complete resection was 23%, compared with a 2% rate (1 of 57) in those treated nonsurgically (p < 0.001). Factors associated with an increased risk of pulmonary metastases included high tumor grade, tumor size greater than 5 cm, lower extremity site, and histologic type (spindle cell, tendosynovial, and extraskeletal osteosarcoma). Factors associated with complete resectability were the histologic types of spindle cell and extraskeletal osteosarcoma. CONCLUSIONS: Complete surgical resection remains the only possibility for cure from pulmonary metastases in soft tissue sarcoma; however, only 11% of the 19% of patients with an extremity sarcoma whose first distant recurrence is in the lung will be alive at 3 years, despite therapy. Complete resection and the development of more effective adjuvant treatments are imperative to improve outcome for this group of patients.
  • |*Extremities[MESH]
  • |*Pneumonectomy[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Lung Neoplasms/epidemiology/*secondary/*surgery[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neoplasm Recurrence, Local/epidemiology[MESH]
  • |Prospective Studies[MESH]
  • |Sarcoma/epidemiology/*secondary/*surgery[MESH]
  • |Soft Tissue Neoplasms/*pathology[MESH]


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