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http://scihub22266oqcxt.onion/ 8228234!ä!8228234 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=8228234&cmd=llinks): Failed to open stream: HTTP request failed! 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Effect of granulocyte/macrophage colony-stimulating factor on human monocytes infected with influenza A virus Enhancement of virus replication, cytokine release, and cytotoxicity |pdf=|usr=}}{{8228234}} gab.com Text Effect of granulocyte/macrophage colony-stimulating factor on human monocytes infected with influenza A virus Enhancement of virus replication, cytokine release, and cytotoxicity JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=8228234 #FOAvip The activating properties of granulocyte/macrophage (GM)-CSF were studied in vitro with human monocytes infected by influenza A virus. When monocytes were pretreated for 8 h with GM-CSF (100 U/ml) and then exposed to influenza A virus, de novo virus protein synthesis was enhanced, more virus particles were released, and cells were killed at a higher rate. In virus-infected monocytes, GM-CSF induced a more rapid IFN-alpha release and potentiated production of TNF-alpha, IL-1 beta, and IL-6. Although GM-CSF or influenza A virus were each capable of independently activating TNF-alpha, IL-1 beta, and IL-6 gene transcription, a combination of both induced a massive cytokine mRNA accumulation which was readily translated into bioactive protein. Thus, GM-CSF may display a Janus-like action by accelerating virus infection but also by priming monocytes for elevated cytokine production. Whether the facilitated influenza A virus replication caused by GM-CSF may be counterbalanced by an improved cytokine response remains to be studied under more complex in vivo conditions. Twit Text FOAVip Effect of granulocyte/macrophage colony-stimulating factor on human monocytes infected with influenza A virus Enhancement of virus replication, cytokine release, and cytotoxicity ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=8228234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8228234 #FOAvip English Wikipedia <ref>{{Cite pmid|8228234}}</ref> Effect of granulocyte/macrophage colony-stimulating factor on human monocytes infected with influenza A virus Enhancement of virus replication, cytokine release, and cytotoxicity #MMPMID8228234 Bender A; Amann U; Jager R; Nain M; Gemsa D J Immunol 1993[Nov]; 151 (10): 5416-24 PMID8228234show ga The activating properties of granulocyte/macrophage (GM)-CSF were studied in vitro with human monocytes infected by influenza A virus. When monocytes were pretreated for 8 h with GM-CSF (100 U/ml) and then exposed to influenza A virus, de novo virus protein synthesis was enhanced, more virus particles were released, and cells were killed at a higher rate. In virus-infected monocytes, GM-CSF induced a more rapid IFN-alpha release and potentiated production of TNF-alpha, IL-1 beta, and IL-6. Although GM-CSF or influenza A virus were each capable of independently activating TNF-alpha, IL-1 beta, and IL-6 gene transcription, a combination of both induced a massive cytokine mRNA accumulation which was readily translated into bioactive protein. Thus, GM-CSF may display a Janus-like action by accelerating virus infection but also by priming monocytes for elevated cytokine production. Whether the facilitated influenza A virus replication caused by GM-CSF may be counterbalanced by an improved cytokine response remains to be studied under more complex in vivo conditions. |Base Sequence[MESH] |Cells, Cultured[MESH] |Cytokines/genetics/*metabolism[MESH] |Cytotoxicity, Immunologic/*drug effects[MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology[MESH] |Humans[MESH] |Influenza A virus/*drug effects/physiology[MESH] |Molecular Sequence Data[MESH] |Monocytes/*drug effects/microbiology/physiology[MESH] |Transcription, Genetic/drug effects[MESH]Effect of granulocyte/macrophage colony-stimulating factor on human mo(epmc).pdf DeepDyve Pubget Overpricing