Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/978-3-7091-9300-6_12 http://scihub22266oqcxt.onion/10.1007/978-3-7091-9300-6_12 8219800!ä!8219800 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Virol+Suppl 1993 ; 7 (ä): 153-8 Nephropedia Template TP {{tp|p=8219800|t=1993. Brain cell lesions in Borna disease are mediated by T cells |pdf=|usr=}}{{8219800}} gab.com Text Brain cell lesions in Borna disease are mediated by T cells JO: Arch Virol Suppl http://www.kidney.de/pget.php?&tw=1&pmid=8219800 #FOAvip Experimental Borna Disease (BD) in rats is characterized by severe lymphocytic encephalitis and by massive brain cell lesions finally leading to brain atrophy. Treatment of BDV-infected rats with monoclonal antibodies directed against CD4+ and CD8+ T cells could almost completely inhibit the immunopathological reactions and revealed less BDV-infected neurons and astrocytes that expressed MHC class I antigen. Brain cell lesions were minimal, and no obvious brain atrophy could be observed even late after infection. Since BDV itself is not known to exert cytopathic effects and since brain cell damage was independent of antibody titers, brain cell destruction correlates well with the intracerebral presence of CD8+ T cells and the expression of MHC class I antigens. Moreover, BDV-infected brain cells in vitro could be demonstrated to be lysed in a MHC class I-restricted manner. These findings provide evidence that virus-infected neurons can be destructed by T cell mediated cytotoxicity which results in organ atrophy and dementia. Twit Text FOAVip Brain cell lesions in Borna disease are mediated by T cells ????Arch Virol Suppl http://www.kidney.de/pget.php?&tw=1&pmid=8219800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8219800 #FOAvip English Wikipedia <ref>{{Cite pmid|8219800}}</ref> Brain cell lesions in Borna disease are mediated by T cells #MMPMID8219800 Bilzer T; Stitz L Arch Virol Suppl 1993[]; 7 (ä): 153-8 PMID8219800show ga Experimental Borna Disease (BD) in rats is characterized by severe lymphocytic encephalitis and by massive brain cell lesions finally leading to brain atrophy. Treatment of BDV-infected rats with monoclonal antibodies directed against CD4+ and CD8+ T cells could almost completely inhibit the immunopathological reactions and revealed less BDV-infected neurons and astrocytes that expressed MHC class I antigen. Brain cell lesions were minimal, and no obvious brain atrophy could be observed even late after infection. Since BDV itself is not known to exert cytopathic effects and since brain cell damage was independent of antibody titers, brain cell destruction correlates well with the intracerebral presence of CD8+ T cells and the expression of MHC class I antigens. Moreover, BDV-infected brain cells in vitro could be demonstrated to be lysed in a MHC class I-restricted manner. These findings provide evidence that virus-infected neurons can be destructed by T cell mediated cytotoxicity which results in organ atrophy and dementia. |Animals[MESH] |Antibodies, Monoclonal/immunology[MESH] |Borna Disease/*immunology/pathology[MESH] |Brain/immunology/microbiology/*pathology[MESH] |Rats[MESH]Brain cell lesions in Borna disease are mediated by T cells (epmc).pdf DeepDyve Pubget Overpricing