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10.1016/0361-9230(94)90183-x

http://scihub22266oqcxt.onion/10.1016/0361-9230(94)90183-x
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8193931!ä!8193931

suck abstract from ncbi


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pmid8193931      Brain+Res+Bull 1994 ; 34 (1): 31-40
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  • Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection #MMPMID8193931
  • Bautista JR; Schwartz GJ; De La Torre JC; Moran TH; Carbone KM
  • Brain Res Bull 1994[]; 34 (1): 31-40 PMID8193931show ga
  • Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.
  • |Animals[MESH]
  • |Animals, Newborn/*physiology[MESH]
  • |Body Weight[MESH]
  • |Borna Disease/*pathology/*physiopathology[MESH]
  • |Borna disease virus[MESH]
  • |Food Preferences[MESH]
  • |Hormones/blood[MESH]
  • |Motor Activity[MESH]
  • |Nervous System Diseases/*pathology/*physiopathology[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]
  • |Solutions[MESH]


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