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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Brain+Res+Bull 1994 ; 34 (1): 31-40 Nephropedia Template TP
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Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection #MMPMID8193931
Bautista JR; Schwartz GJ; De La Torre JC; Moran TH; Carbone KM
Brain Res Bull 1994[]; 34 (1): 31-40 PMID8193931show ga
Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.
|Animals[MESH]
|Animals, Newborn/*physiology[MESH]
|Body Weight[MESH]
|Borna Disease/*pathology/*physiopathology[MESH]
|Borna disease virus[MESH]
|Food Preferences[MESH]
|Hormones/blood[MESH]
|Motor Activity[MESH]
|Nervous System Diseases/*pathology/*physiopathology[MESH]