Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

http://scihub22266oqcxt.onion/ 8030743/?report=reader!1887293!8030743     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=8030743&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 1994 ; 145 (1): 11-7 Nephropedia Template TP {{tp|p=8030743|t=1994. Ultraviolet-induced p53 mutations in atypical fibroxanthoma |pdf=|usr=}}{{8030743}} gab.com Text Ultraviolet-induced p53 mutations in atypical fibroxanthoma JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=8030743 #FOAvip Atypical fibroxanthoma (AFX) is an uncommon neoplasm of the superficial soft tissue occurring in actinically damaged skin of elderly patients. Sun-exposed skin also represents the main site of squamous and basal cell carcinomas and malignant melanoma, and a key role for ultraviolet (UV) radiation in their pathogenesis has long been suspected. UV-related mutations of the p53 gene have been identified in human skin cancers. To verify whether the pathogenesis of AFX is related to the effect of sunlight, p53 protein and gene status have been investigated in a series of 10 cases of AFX. Seven of 10 showed p53 immunoreactivity in most of the neoplastic cells. Molecular analysis of the p53 gene revealed an abnormal single strand conformation polymorphism pattern in all the p53 positive cases. Polymerase chain reaction direct sequencing revealed that all the mutations involved cytosine bases. Four cases showed C to T transitions (including two CC-TT double base substitutions) and two cases showed C to G transversion. All but one mutation took place at dipyrimidine sites. These findings provide the first objective evidence for the central role of UV radiation in the development of AFX and also represent the first in vivo demonstration of solar UV-induced mutations in a human mesenchymal neoplasm. Twit Text FOAVip Ultraviolet-induced p53 mutations in atypical fibroxanthoma ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=8030743 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8030743 #FOAvip English Wikipedia <ref>{{Cite pmid|8030743}}</ref> Ultraviolet-induced p53 mutations in atypical fibroxanthoma #MMPMID8030743 Dei Tos AP; Maestro R; Doglioni C; Gasparotto D; Boiocchi M; Laurino L; Fletcher CD Am J Pathol 1994[Jul]; 145 (1): 11-7 PMID8030743show ga Atypical fibroxanthoma (AFX) is an uncommon neoplasm of the superficial soft tissue occurring in actinically damaged skin of elderly patients. Sun-exposed skin also represents the main site of squamous and basal cell carcinomas and malignant melanoma, and a key role for ultraviolet (UV) radiation in their pathogenesis has long been suspected. UV-related mutations of the p53 gene have been identified in human skin cancers. To verify whether the pathogenesis of AFX is related to the effect of sunlight, p53 protein and gene status have been investigated in a series of 10 cases of AFX. Seven of 10 showed p53 immunoreactivity in most of the neoplastic cells. Molecular analysis of the p53 gene revealed an abnormal single strand conformation polymorphism pattern in all the p53 positive cases. Polymerase chain reaction direct sequencing revealed that all the mutations involved cytosine bases. Four cases showed C to T transitions (including two CC-TT double base substitutions) and two cases showed C to G transversion. All but one mutation took place at dipyrimidine sites. These findings provide the first objective evidence for the central role of UV radiation in the development of AFX and also represent the first in vivo demonstration of solar UV-induced mutations in a human mesenchymal neoplasm. |Base Sequence[MESH] |Genes, p53/*genetics/radiation effects[MESH] |Histiocytoma, Benign Fibrous/etiology/*genetics[MESH] |Humans[MESH] |Molecular Sequence Data[MESH] |Mutation/*genetics[MESH] |Skin Neoplasms/etiology/*genetics[MESH]Ultraviolet-induced p53 mutations in atypical fibroxanthoma (epmc).pdf DeepDyve Pubget Overpricing