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suck abstract from ncbi


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pmid8002906      Avian+Dis 1994 ; 38 (1): 93-102
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  • Effect of avian influenza virus infection on the phagocytic function of systemic phagocytes and pulmonary macrophages of turkeys #MMPMID8002906
  • Kodihalli S; Sivanandan V; Nagaraja KV; Shaw D; Halvorson DA
  • Avian Dis 1994[Jan]; 38 (1): 93-102 PMID8002906show ga
  • The effects of avian influenza virus (AIV) infection on systemic phagocytes and pulmonary macrophages of turkeys were studied. There was a significant increase (P < 0.0001) in oxidative burst in systemic phagocytes of AIV-inoculated turkeys on 2, 4, 6, and 8 days postinoculation (PI), as measured by chemiluminescence. There was also a significant increase (P < 0.02) in oxidative burst in pulmonary macrophages on day 4 PI. The chemiluminescence response was depressed on 6, 8, and 10 days PI in AIV-inoculated turkeys compared with controls. The increase in oxidative response in both systemic phagocytes and pulmonary macrophages correlated with the peak virus titer in the lungs and trachea of AIV-inoculated inoculated turkeys. Bacterial killing by pulmonary macrophages from AIV-inoculated turkeys was reduced on days 6 and 10 PI compared with uninoculated controls. Histopathological changes in trachea were more pronounced on day 6 PI in AIV-inoculated turkeys; no significant changes were detected in the lungs. These data indicate that compromised functional capacity of pulmonary macrophages predisposes turkeys to secondary bacterial infections.
  • |*Phagocytosis[MESH]
  • |Animals[MESH]
  • |Cell Separation[MESH]
  • |Cells, Cultured[MESH]
  • |Chick Embryo[MESH]
  • |Escherichia coli[MESH]
  • |Influenza A virus/growth & development/isolation & purification[MESH]
  • |Influenza in Birds/pathology/*physiopathology[MESH]
  • |Luminescent Measurements[MESH]
  • |Lung/pathology[MESH]
  • |Macrophages, Alveolar/*physiology[MESH]
  • |Mucous Membrane/pathology[MESH]
  • |Phagocytes/*physiology[MESH]
  • |Trachea/pathology[MESH]


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