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10.1002/jlb.56.5.588 http://scihub22266oqcxt.onion/10.1002/jlb.56.5.588 7964166!ä!7964166 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Leukoc+Biol 1994 ; 56 (5): 588-92 Nephropedia Template TP {{tp|p=7964166|t=1994. Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger |pdf=|usr=}}{{7964166}} gab.com Text Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=7964166 #FOAvip A wide range of biological functions of nitric oxide (NO) was analyzed using a newly discovered nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazolineoxyl-1-oxyl-3-oxide (PTIO) or its water-soluble derivative carboxy-PTIO. The chemistry is very simple in that NO was oxidized by PTIO, yielding one mole each of NO2 and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl. Based on the potent NO-scavenging activity of PTIO derivatives, the diverse functions of NO under physiological states as well as various pathological conditions such as endotoxin shock and viral diseases are now explicated. It was found that PTIO and carboxy-PTIO showed significant inhibitory activity against a series of biological actions of NO: (1) endothelium-dependent vascular relaxation in an ex vivo system, (2) pathogenicity of NO produced excessively in endotoxin shock in rats and in influenza virus pneumonitis in mice, and (3) enhanced vascular permeability in solid tumors mediated by NO. PTIO directly extinguishes NO generated by NO synthase (NOS) without affecting NOS activity, which is a clear contrast to NOS inhibitors. Therefore, characterization of this unique mode of action of PTIO appears to be helpful not only in understanding of the pathophysiological role of NO but also in the treatment of various diseases caused by excessive production of NO. Twit Text FOAVip Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=7964166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=7964166 #FOAvip English Wikipedia <ref>{{Cite pmid|7964166}}</ref> Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger #MMPMID7964166 Maeda H; Akaike T; Yoshida M; Suga M J Leukoc Biol 1994[Nov]; 56 (5): 588-92 PMID7964166show ga A wide range of biological functions of nitric oxide (NO) was analyzed using a newly discovered nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazolineoxyl-1-oxyl-3-oxide (PTIO) or its water-soluble derivative carboxy-PTIO. The chemistry is very simple in that NO was oxidized by PTIO, yielding one mole each of NO2 and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl. Based on the potent NO-scavenging activity of PTIO derivatives, the diverse functions of NO under physiological states as well as various pathological conditions such as endotoxin shock and viral diseases are now explicated. It was found that PTIO and carboxy-PTIO showed significant inhibitory activity against a series of biological actions of NO: (1) endothelium-dependent vascular relaxation in an ex vivo system, (2) pathogenicity of NO produced excessively in endotoxin shock in rats and in influenza virus pneumonitis in mice, and (3) enhanced vascular permeability in solid tumors mediated by NO. PTIO directly extinguishes NO generated by NO synthase (NOS) without affecting NOS activity, which is a clear contrast to NOS inhibitors. Therefore, characterization of this unique mode of action of PTIO appears to be helpful not only in understanding of the pathophysiological role of NO but also in the treatment of various diseases caused by excessive production of NO. |Animals[MESH] |Aorta/drug effects[MESH] |Blood Pressure/drug effects[MESH] |Capillary Permeability/drug effects[MESH] |Cryptococcus neoformans/drug effects[MESH] |Cyclic N-Oxides/metabolism/*pharmacology[MESH] |Imidazoles/metabolism/*pharmacology[MESH] |Lipopolysaccharides[MESH] |Macrophages/metabolism/physiology[MESH] |Male[MESH] |Mice[MESH] |Neoplasms, Experimental/blood supply[MESH] |Nitric Oxide/antagonists & inhibitors/metabolism/*physiology[MESH] |Rabbits[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Shock, Septic/prevention & control[MESH] |Staphylococcus aureus/drug effects[MESH] |Superoxides/metabolism[MESH] |Vasodilation/drug effects[MESH]Multiple functions of nitric oxide in pathophysiology and microbiology(epmc).pdf DeepDyve Pubget Overpricing