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http://scihub22266oqcxt.onion/ 7912707!ä!7912707 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 1994 ; 153 (2): 818-23 Nephropedia Template TP {{tp|p=7912707|t=1994. Immune-mediated brain atrophy CD8+ T cells contribute to tissue destruction during borna disease |pdf=|usr=}}{{7912707}} gab.com Text Immune-mediated brain atrophy CD8+ T cells contribute to tissue destruction during borna disease JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=7912707 #FOAvip Borna disease (BD) is a virus-induced immunopathologic disease of the central nervous system in a variety of species from birds to primates and probably in humans. Severe inflammatory reactions lead to tissue destruction and finally to cortical brain atrophy. After experimental infection of the rat, intraparenchymal CD8+ T cells, MHC class I Ags on Borna disease virus (BDV)-infected neurons, and numerous nerve cell lesions were present. Treatment of BDV-infected rats with the mAb OX-8 directed against CD8+ cells inhibited the immunopathologic reactions and reduced MHC class I Ag expression. Neuronal lesions were minimal and no loss of brain substance could be observed. Because BDV has no acute cytopathic effects, we provide evidence that the presence of CD8+ T cells within the brain parenchyma and the expression of MHC class I Ags on neurons play a major role for immunopathologic brain tissue destruction and virus-infected neurons in vivo can be destroyed by T cell-mediated cytotoxicity. Twit Text FOAVip Immune-mediated brain atrophy CD8+ T cells contribute to tissue destruction during borna disease ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=7912707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=7912707 #FOAvip English Wikipedia <ref>{{Cite pmid|7912707}}</ref> Immune-mediated brain atrophy CD8+ T cells contribute to tissue destruction during borna disease #MMPMID7912707 Bilzer T; Stitz L J Immunol 1994[Jul]; 153 (2): 818-23 PMID7912707show ga Borna disease (BD) is a virus-induced immunopathologic disease of the central nervous system in a variety of species from birds to primates and probably in humans. Severe inflammatory reactions lead to tissue destruction and finally to cortical brain atrophy. After experimental infection of the rat, intraparenchymal CD8+ T cells, MHC class I Ags on Borna disease virus (BDV)-infected neurons, and numerous nerve cell lesions were present. Treatment of BDV-infected rats with the mAb OX-8 directed against CD8+ cells inhibited the immunopathologic reactions and reduced MHC class I Ag expression. Neuronal lesions were minimal and no loss of brain substance could be observed. Because BDV has no acute cytopathic effects, we provide evidence that the presence of CD8+ T cells within the brain parenchyma and the expression of MHC class I Ags on neurons play a major role for immunopathologic brain tissue destruction and virus-infected neurons in vivo can be destroyed by T cell-mediated cytotoxicity. |Animals[MESH] |Atrophy[MESH] |Borna Disease/immunology/*pathology[MESH] |Brain/immunology/*pathology[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |CD8 Antigens/*analysis[MESH] |Histocompatibility Antigens Class I/analysis[MESH] |Rats[MESH] |Rats, Inbred Lew[MESH]Immune-mediated brain atrophy CD8+ T cells contribute to tissue destr(epmc).pdf DeepDyve Pubget Overpricing