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10.1152/ajpcell.1993.265.6.C1663 http://scihub22266oqcxt.onion/10.1152/ajpcell.1993.265.6.C1663 7904123!ä!7904123 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=7904123&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol 1993 ; 265 (6 Pt 1): C1663-73 Nephropedia Template TP {{tp|p=7904123|t=1993. ATP- and UTP-induced currents in macrophages and macrophage polykaryons |pdf=|usr=}}{{7904123}} gab.com Text ATP- and UTP-induced currents in macrophages and macrophage polykaryons JO: Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=7904123 #FOAvip We have investigated the currents induced by extracellular ATP (ATPo), extra-cellular UTP, and other related compounds in macrophages. At potentials of -20 to -60 mV, a typical response to ATPo puffs consists of a fast-activating inward current followed by a transient outward current. The phenomenon lasts 5-20 s, but for sustained exposure to ATP the inward current persists for up to 10 min (our longest recording time). Both currents are inhibited by Mg2+, suggesting that the phenomenon is mediated by ATP4-. The outward current can be ascribed to a Ca(2+)-dependent K+ conductance, and release of Ca2+ from intracellular stores is at least in part responsible for this current. The inward current has a reversal potential of approximately 0 mV, and it is nonspecific for monovalent cations. UTP, a nucleotide that induces an increase in the cytoplasmic concentration of free Ca2+ but does not permeabilize macrophages, and ATP-gamma-S can also induce inward and outward current similar to those described for ATP, but higher doses are required. Adenosine and AMP produce no detectable effect, whereas ADP induces a small outward current. The implications of these results to the phenomenon of ATPo-induced permeabilization of macrophage membranes to large molecules are discussed. Twit Text FOAVip ATP- and UTP-induced currents in macrophages and macrophage polykaryons ????Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=7904123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=7904123 #FOAvip English Wikipedia <ref>{{Cite pmid|7904123}}</ref> ATP- and UTP-induced currents in macrophages and macrophage polykaryons #MMPMID7904123 Albuquerque C; Oliveira SM; Coutinho-Silva R; Oliveira-Castro GM; Persechini PM Am J Physiol 1993[Dec]; 265 (6 Pt 1): C1663-73 PMID7904123show ga We have investigated the currents induced by extracellular ATP (ATPo), extra-cellular UTP, and other related compounds in macrophages. At potentials of -20 to -60 mV, a typical response to ATPo puffs consists of a fast-activating inward current followed by a transient outward current. The phenomenon lasts 5-20 s, but for sustained exposure to ATP the inward current persists for up to 10 min (our longest recording time). Both currents are inhibited by Mg2+, suggesting that the phenomenon is mediated by ATP4-. The outward current can be ascribed to a Ca(2+)-dependent K+ conductance, and release of Ca2+ from intracellular stores is at least in part responsible for this current. The inward current has a reversal potential of approximately 0 mV, and it is nonspecific for monovalent cations. UTP, a nucleotide that induces an increase in the cytoplasmic concentration of free Ca2+ but does not permeabilize macrophages, and ATP-gamma-S can also induce inward and outward current similar to those described for ATP, but higher doses are required. Adenosine and AMP produce no detectable effect, whereas ADP induces a small outward current. The implications of these results to the phenomenon of ATPo-induced permeabilization of macrophage membranes to large molecules are discussed. |Adenosine Diphosphate/pharmacology[MESH] |Adenosine Monophosphate/pharmacology[MESH] |Adenosine Triphosphate/analogs & derivatives/*pharmacology[MESH] |Adenosine/pharmacology[MESH] |Animals[MESH] |Calcium/metabolism[MESH] |Cell Membrane/drug effects/physiology[MESH] |Cells, Cultured[MESH] |Cytosol/metabolism[MESH] |Egtazic Acid/pharmacology[MESH] |Electric Stimulation[MESH] |Glutamates/pharmacology[MESH] |Glutamic Acid[MESH] |Macrophages, Peritoneal/drug effects/*physiology[MESH] |Magnesium/pharmacology[MESH] |Meglumine/pharmacology[MESH] |Membrane Potentials/drug effects/physiology[MESH] |Mice[MESH] |Models, Biological[MESH] |Potassium Channels/drug effects/*physiology[MESH] |Quinine/pharmacology[MESH]ATP- and UTP-induced currents in macrophages and macrophage polykaryon(epmc).pdf DeepDyve Pubget Overpricing