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10.1126/science.7667639 http://scihub22266oqcxt.onion/10.1126/science.7667639 7667639!ä!7667639 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 1995 ; 269 (5230): 1583-5 Nephropedia Template TP {{tp|p=7667639|t=1995. Requirement of MIP-1 alpha for an inflammatory response to viral infection |pdf=|usr=}}{{7667639}} gab.com Text Requirement of MIP-1 alpha for an inflammatory response to viral infection JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=7667639 #FOAvip Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo. Twit Text FOAVip Requirement of MIP-1 alpha for an inflammatory response to viral infection ????Science http://www.kidney.de/pget.php?&tw=1&pmid=7667639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=7667639 #FOAvip English Wikipedia <ref>{{Cite pmid|7667639}}</ref> Requirement of MIP-1 alpha for an inflammatory response to viral infection #MMPMID7667639 Cook DN; Beck MA; Coffman TM; Kirby SL; Sheridan JF; Pragnell IB; Smithies O Science 1995[Sep]; 269 (5230): 1583-5 PMID7667639show ga Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo. |*Enterovirus B, Human/growth & development/immunology[MESH] |*Influenza A virus/growth & development/immunology[MESH] |Animals[MESH] |Antibodies, Viral/blood[MESH] |B-Lymphocytes/immunology[MESH] |Base Sequence[MESH] |Chemokine CCL4[MESH] |Coxsackievirus Infections/*immunology/virology[MESH] |Cytokines/genetics/*physiology[MESH] |Gene Targeting[MESH] |Hematopoiesis[MESH] |Lymphocyte Activation[MESH] |Macrophage Inflammatory Proteins[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Molecular Sequence Data[MESH] |Monokines/genetics/*physiology[MESH] |Myocarditis/*immunology/virology[MESH] |Neutralization Tests[MESH] |Orthomyxoviridae Infections/*immunology/virology[MESH] |Stem Cells[MESH]Requirement of MIP-1 alpha for an inflammatory response to viral infec(epmc).pdf DeepDyve Pubget Overpricing