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7610751!ä!7610751

suck abstract from ncbi


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pmid7610751      Acta+Chir+Belg 1995 ; 95 (3): 162-5
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  • Piperacillin-tazobactam treatment for severe intra-abdominal infections #MMPMID7610751
  • Legrand JC; Bastin F; Belva P; Chastel C; Renaux J; Van Eukem P
  • Acta Chir Belg 1995[May]; 95 (3): 162-5 PMID7610751show ga
  • In this limited series of 23 patients suffering from severe or life-threatening intra-abdominal infection, piperacillin + tazobactam, together with adequate surgical drainage and resections, cured 78% of our patients and eradicated almost all the pathogens. Side effects included essentially eosinophilia and elevation of transaminases but was never severe. Piperacillin + tazobactam seem thus to be an acceptable treatment, associated with correct surgical drainage. This regimen has to be compared in appropriate trial versus gold standard therapy, such as imipenem, a beta-lactam with aminoglucoside and imidazole or clindamycin or with broad spectrum beta-lactam and other inhibitors or beta-lactamases, but our rate of cure is impressive in such a population.
  • |Abdomen/surgery[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Drainage[MESH]
  • |Drug Therapy, Combination/*therapeutic use[MESH]
  • |Eosinophilia/chemically induced[MESH]
  • |Female[MESH]
  • |Gram-Negative Bacterial Infections/*drug therapy/surgery[MESH]
  • |Gram-Positive Bacterial Infections/*drug therapy/surgery[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Penicillanic Acid/administration & dosage/adverse effects/*analogs & derivatives[MESH]
  • |Piperacillin/*administration & dosage/adverse effects[MESH]
  • |Tazobactam[MESH]


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