Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/0006-2952(75)90018-0 http://scihub22266oqcxt.onion/10.1016/0006-2952(75)90018-0 7495279Ringchromosomesindermatofibrosarcomaprotuberansarecomposedofinterspersedsequencesfromchromosomes17and22.!1869963!7495279; 17; 22     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=7495279; 17; 22&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 400 Bad Request in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 245.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 279.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 279.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 279.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 279.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 312.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 346.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 413.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 413.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 413.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol;+Biochem+Pharmacol;+Arzneimittelforschung 1995 ; 147; 24; 25 (6; 18; 9): 1553-8; 1739-42; 1369-79 Nephropedia Template TP {{tp|p=7495279; 17; 22|t=1995. Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden Verbindung kleiner Molekulmasse Versuche am immunlabilen DS-Karzinosarkom im Vergleich mit Ifosfamid Stimulierung der korpereigenen Abwehr uber etwa 20 Tage durch BA 1, einen N-(2-Cyanthylen)-harnstoff Neue prophylaktische Moglichkeiten |pdf=|usr=}}{{7495279; 17; 22}} gab.com Text Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden Verbindung kleiner Molekulmasse Versuche am immunlabilen DS-Karzinosarkom im Vergleich mit Ifosfamid Stimulierung der korpereigenen Abwehr uber etwa 20 Tage durch BA 1, einen N-(2-Cyanthylen)-harnstoff Neue prophylaktische Moglichkeiten JO: Am J Pathol; Biochem Pharmacol; Arzneimittelforschung http://www.kidney.de/pget.php?&tw=1&pmid=7495279; 17; 22 #FOAvip Ring chromosomes are found in most dermatofibrosarcoma protuberans (DFSPs), and recent reports demonstrate that portions of the DFSP ring chromosomes derive from chromosome 17. In this study we characterized ring chromosomes in three DFSPs using a combined approach of karyotyping, chromosome painting, and comparative genomic hybridization. Chromosome painting demonstrated that the ring chromosomes in each DFSP were composed of discontinuous, interwoven sequences from chromosomes 17 and 22. Amplification of chromosomes 17 and 22 sequences was confirmed in each of these cases by comparative genomic hybridization, and over-representation of chromosomes 17 and 22 sequences was also demonstrated by comparative genomic hybridization in 1 of 2 cytogenetically unremarkable DFSPs. We conclude that amplification of chromosomes 17 and 22 sequences, in ring form, is a characteristic aberration in DFSP.; A report is given on the recent discovery of outstanding immunological properties in BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40 percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. Under otherwise unchanged conditions the reference substance ifosfamide (IF) -- a further development of cyclophosphamide -- applied without hyperglycemia in its most efficient dosage of 47 percent LD50 (150 mg kg) brought about a recovery rate of 25 percent at a lethality of 18 percent. (Contrary to BA 1, 250-min hyperglycemia caused no further improvement of the recovery rate.) However this comparison is characterized by the fact that both substances exhibit two quite different (complementary) mechanisms of action. Leucocyte counts made after application of the said cancerostatics and dosages have shown a pronounced stimulation with BA 1 and with ifosfamide, the known suppression in the post-therapeutic interval usually found with standard cancerostatics. In combination with the cited plaque test for BA 1, blood pictures then allow conclusions on the immunity status. Since IF can be taken as one of the most efficient cancerostatics--there is no other chemotherapeutic known up to now that has a more significant effect on the DS carcinosarcoma in rats -- these findings are of special importance. Finally, the total amount of leucocytes and lymphocytes as well as their time behaviour was determined from the blood picture of tumour-free rats after i.v. application of BA 1. The thus obtained numerical values clearly show that further research work on the prophylactic use of this substance seems to be necessary and very promising. Twit Text FOAVip Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden Verbindung kleiner Molekulmasse Versuche am immunlabilen DS-Karzinosarkom im Vergleich mit Ifosfamid Stimulierung der korpereigenen Abwehr uber etwa 20 Tage durch BA 1, einen N-(2-Cyanthylen)-harnstoff Neue prophylaktische Moglichkeiten ????Am J Pathol; Biochem Pharmacol; Arzneimittelforschung http://www.kidney.de/pget.php?&tw=1&pmid=7495279; 17; 22 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=7495279; 17; 22 #FOAvip English Wikipedia <ref>{{Cite pmid|7495279; 17; 22}}</ref> Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden Verbindung kleiner Molekulmasse Versuche am immunlabilen DS-Karzinosarkom im Vergleich mit Ifosfamid Stimulierung der korpereigenen Abwehr uber etwa 20 Tage durch BA 1, einen N-(2-Cyanthylen)-harnstoff Neue prophylaktische Moglichkeiten #MMPMID7495279; 17; 22 Naeem R; Lux ML; Huang SF; Naber SP; Corson JM; Fletcher JA; Renaud B; Buda M; Lewis BD; Pujol JF; Ardenne M; Reitnauer PG Am J Pathol; Biochem Pharmacol; Arzneimittelforschung 1995[Dec]; 147; 24; 25 (6; 18; 9): 1553-8; 1739-42; 1369-79 PMID7495279; 17; 22show ga Ring chromosomes are found in most dermatofibrosarcoma protuberans (DFSPs), and recent reports demonstrate that portions of the DFSP ring chromosomes derive from chromosome 17. In this study we characterized ring chromosomes in three DFSPs using a combined approach of karyotyping, chromosome painting, and comparative genomic hybridization. Chromosome painting demonstrated that the ring chromosomes in each DFSP were composed of discontinuous, interwoven sequences from chromosomes 17 and 22. Amplification of chromosomes 17 and 22 sequences was confirmed in each of these cases by comparative genomic hybridization, and over-representation of chromosomes 17 and 22 sequences was also demonstrated by comparative genomic hybridization in 1 of 2 cytogenetically unremarkable DFSPs. We conclude that amplification of chromosomes 17 and 22 sequences, in ring form, is a characteristic aberration in DFSP.; A report is given on the recent discovery of outstanding immunological properties in BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40 percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. Under otherwise unchanged conditions the reference substance ifosfamide (IF) -- a further development of cyclophosphamide -- applied without hyperglycemia in its most efficient dosage of 47 percent LD50 (150 mg kg) brought about a recovery rate of 25 percent at a lethality of 18 percent. (Contrary to BA 1, 250-min hyperglycemia caused no further improvement of the recovery rate.) However this comparison is characterized by the fact that both substances exhibit two quite different (complementary) mechanisms of action. Leucocyte counts made after application of the said cancerostatics and dosages have shown a pronounced stimulation with BA 1 and with ifosfamide, the known suppression in the post-therapeutic interval usually found with standard cancerostatics. In combination with the cited plaque test for BA 1, blood pictures then allow conclusions on the immunity status. Since IF can be taken as one of the most efficient cancerostatics--there is no other chemotherapeutic known up to now that has a more significant effect on the DS carcinosarcoma in rats -- these findings are of special importance. Finally, the total amount of leucocytes and lymphocytes as well as their time behaviour was determined from the blood picture of tumour-free rats after i.v. application of BA 1. The thus obtained numerical values clearly show that further research work on the prophylactic use of this substance seems to be necessary and very promising. |*Ifosfamide/pharmacology/therapeutic use[MESH] |*Ring Chromosomes[MESH] |5,6-Dihydroxytryptamine/administration & dosage/*pharmacology[MESH] |Adult[MESH] |Animals[MESH] |Antineoplastic Agents/pharmacology/*therapeutic use[MESH] |Brain/enzymology[MESH] |Carcinosarcoma/*drug therapy[MESH] |Catecholamines/*physiology[MESH] |Cerebral Cortex/enzymology[MESH] |Chromosomes, Human, Pair 17/*genetics[MESH] |Chromosomes, Human, Pair 22/*genetics[MESH] |Cisterna Magna[MESH] |Corpus Striatum/enzymology[MESH] |Cyclophosphamide/*analogs & derivatives[MESH] |Cytogenetics/methods[MESH] |Dermatofibrosarcoma/*genetics[MESH] |Drug Evaluation, Preclinical[MESH] |Drug Tolerance[MESH] |Erythrocyte Count[MESH] |Female[MESH] |Humans[MESH] |Hydrogen-Ion Concentration[MESH] |Hyperglycemia[MESH] |Immunity/*drug effects[MESH] |Immunosuppression Therapy[MESH] |In Vitro Techniques[MESH] |Injections[MESH] |Lethal Dose 50[MESH] |Leukocyte Count[MESH] |Male[MESH] |Mice[MESH] |Middle Aged[MESH] |Neoplasms, Experimental/drug therapy[MESH] |Neurons/*enzymology[MESH] |Rats[MESH] |Rats, Inbred Strains[MESH] |Skin Neoplasms/*genetics[MESH] |Stimulation, Chemical[MESH] |Substantia Nigra/enzymology[MESH] |Time Factors[MESH] |Tryptamines/*pharmacology[MESH] |Tyrosine 3-Monooxygenase/*metabolism[MESH]Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden (epmc).pdf DeepDyve Pubget Overpricing