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Mineralocorticoid receptor blockade in chronic heart failure #MMPMID7473525
Struthers AD
J Hum Hypertens 1995[Jun]; 9 (6): 443-6 PMID7473525show ga
The effects of ACE inhibitors on plasma aldosterone in chronic heart failure are poor, variable and unsustained. This is important to recognise because aldosterone has many harmful properties of its own. Aldosterone causes magnesium loss, potentiates catecholamines, induces ventricular arrhythmias, alters baroreflex function and stimulates myocardial fibrosis. Strategies to reduce these effects of aldosterone are being explored.