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10.1093/nar/5.6.2197 http://scihub22266oqcxt.onion/10.1093/nar/5.6.2197 673850!342153!673850     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 1978 ; 5 (6): 2197-210 Nephropedia Template TP {{tp|p=673850|t=1978. The inhibition of mitochondrial DNA polymerase gamma from animal cells by intercalating drugs |pdf=|usr=}}{{673850}} gab.com Text The inhibition of mitochondrial DNA polymerase gamma from animal cells by intercalating drugs JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=673850 #FOAvip DNA polymerase gamma from purified nuclei of EMT-6 cells (mice) seems to be identical to the mitochondrial DNA polymerase from the same source following several criteria. These two enzyme activities are strongly inhibited by ethidium bromide and acriflavin, while proflavin, acridine orange, daunomycin and chloroquine inhibition is less pronounced. In the case of DNA polymerases alpha and beta very little inhibition by ethidium bromide was observed. Intercalation of this dye in a poly dA-dT 12-18 template-primer was studied spectrophotometrically under conditions similar to those in the in vitro DNA polymerase assay. The polymerase assay. The inhibition by this drug of the mitochondrial DNA polymerase gamma activity was shown to be competitive at varying concentrations of TTP while the inhibition was of the non-competitive type at different concentrations of poly dA-dT 12-18. We conclude that the drug, most probably in the intercalated form, is able to interact with the active site (s) of mitochondrial DNA polymerase. Twit Text FOAVip The inhibition of mitochondrial DNA polymerase gamma from animal cells by intercalating drugs ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=673850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=673850 #FOAvip English Wikipedia <ref>{{Cite pmid|673850}}</ref> The inhibition of mitochondrial DNA polymerase gamma from animal cells by intercalating drugs #MMPMID673850 Tarrago-Litvak L; Viratelle O; Darriet D; Dalibart R; Graves PV; Litvak S Nucleic Acids Res 1978[Jun]; 5 (6): 2197-210 PMID673850show ga DNA polymerase gamma from purified nuclei of EMT-6 cells (mice) seems to be identical to the mitochondrial DNA polymerase from the same source following several criteria. These two enzyme activities are strongly inhibited by ethidium bromide and acriflavin, while proflavin, acridine orange, daunomycin and chloroquine inhibition is less pronounced. In the case of DNA polymerases alpha and beta very little inhibition by ethidium bromide was observed. Intercalation of this dye in a poly dA-dT 12-18 template-primer was studied spectrophotometrically under conditions similar to those in the in vitro DNA polymerase assay. The polymerase assay. The inhibition by this drug of the mitochondrial DNA polymerase gamma activity was shown to be competitive at varying concentrations of TTP while the inhibition was of the non-competitive type at different concentrations of poly dA-dT 12-18. We conclude that the drug, most probably in the intercalated form, is able to interact with the active site (s) of mitochondrial DNA polymerase. |*Nucleic Acid Synthesis Inhibitors[MESH] |Cell Line[MESH] |DNA Polymerase I/metabolism[MESH] |DNA Polymerase II/metabolism[MESH] |DNA Polymerase III/*antagonists & inhibitors[MESH] |Enzyme Inhibitors/*pharmacology[MESH] |Ethidium/pharmacology[MESH] |Kinetics[MESH] |Magnesium/pharmacology[MESH] |Manganese/pharmacology[MESH] |Mitochondria/*enzymology[MESH]The inhibition of mitochondrial DNA polymerase gamma from animal cells(epmc).pdf DeepDyve Pubget Overpricing