Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/BF00542150 http://scihub22266oqcxt.onion/10.1007/BF00542150 6734710!ä!6734710 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Clin+Pharmacol 1984 ; 26 (4): 513-20 Nephropedia Template TP {{tp|p=6734710|t=1984. Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function |pdf=|usr=}}{{6734710}} gab.com Text Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function JO: Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=6734710 #FOAvip The effect of a single oral dose of 40 mg xipamide on urinary excretion of Na+, K+, Cl-, Ca2+ and Mg2+ in healthy subjects and in patients with varying degrees of renal impairment was compared with various conventional diuretics. Xipamide caused marked excretion of Na+ and Cl-, whereas the diuretic produced only moderate kaliuresis; urinary excretion of Ca2+ was increased in proportion to Na+, like the loop diuretics. Xipamide affected electrolyte excretion even in patients with a creatinine clearance below 30 ml/min, as do the loop diuretics, too. Therefore, the pharmacodynamic characteristics of xipamide are more like those of a loop diuretic than of a thiazide. Xipamide was good bioavailable, its t 1/2 beta was 7 h and urinary recovery of the undegraded drug was 40% of the given dose. In renal insufficiency, t 1/2 beta increased from 7 to only 9h, yielding a moderate increase in the AUC. Urinary recovery of the drug was reduced in proportion to the reduction in the creatinine clearance of the patient. Therefore, significant extrarenal elimination of the diuretic must be postulated, which suffices to prevent significant drug accumulation in renal failure. Twit Text FOAVip Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function ????Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=6734710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6734710 #FOAvip English Wikipedia <ref>{{Cite pmid|6734710}}</ref> Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function #MMPMID6734710 Knauf H; Mutschler E Eur J Clin Pharmacol 1984[]; 26 (4): 513-20 PMID6734710show ga The effect of a single oral dose of 40 mg xipamide on urinary excretion of Na+, K+, Cl-, Ca2+ and Mg2+ in healthy subjects and in patients with varying degrees of renal impairment was compared with various conventional diuretics. Xipamide caused marked excretion of Na+ and Cl-, whereas the diuretic produced only moderate kaliuresis; urinary excretion of Ca2+ was increased in proportion to Na+, like the loop diuretics. Xipamide affected electrolyte excretion even in patients with a creatinine clearance below 30 ml/min, as do the loop diuretics, too. Therefore, the pharmacodynamic characteristics of xipamide are more like those of a loop diuretic than of a thiazide. Xipamide was good bioavailable, its t 1/2 beta was 7 h and urinary recovery of the undegraded drug was 40% of the given dose. In renal insufficiency, t 1/2 beta increased from 7 to only 9h, yielding a moderate increase in the AUC. Urinary recovery of the drug was reduced in proportion to the reduction in the creatinine clearance of the patient. Therefore, significant extrarenal elimination of the diuretic must be postulated, which suffices to prevent significant drug accumulation in renal failure. |Adult[MESH] |Aged[MESH] |Biological Availability[MESH] |Diuresis/drug effects[MESH] |Diuretics/*pharmacology[MESH] |Female[MESH] |Humans[MESH] |Kidney Failure, Chronic/*drug therapy/physiopathology[MESH] |Kidney/metabolism/*physiology[MESH] |Kinetics[MESH] |Male[MESH] |Middle Aged[MESH] |Time Factors[MESH] |Water-Electrolyte Balance/drug effects[MESH]Pharmacodynamics and pharmacokinetics of xipamide in patients with nor(epmc).pdf DeepDyve Pubget Overpricing