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pmid6696048      Am+J+Pathol 1984 ; 114 (3): 367-79
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  • Ultrastructural alterations in the atrial myocardium of pigs with acute monensin toxicosis #MMPMID6696048
  • Van Vleet JF; Ferrans VJ
  • Am J Pathol 1984[Mar]; 114 (3): 367-79 PMID6696048show ga
  • Monensin, A Na+-selective carboxylic ionophore, produces left atrial damage in pigs given toxic doses. Eight weanling pigs were given mycelial monensin orally (40 mg/kg body weight) and were killed on days 1, 2, 4, and 16 (two animals at each time interval) for ultrastructural study of the left atrial lesions. On days 1-4, extensive necrosis with contraction bands was present. Rapid macrophagic invasion and phagocytosis of sarcoplasmic debris was seen on days 2 and 4. Missing necrotic myocytes were outlined by persistent "tubes" of external laminas. In some surviving myocytes, sublethal injury was evident on day 1 by mitochondria with condensed conformation and on days 2, 4, and 16 by moderate to marked myofibrillar lysis and sarcoplasmic vacuolation. Monensin cardiotoxicity in pigs constitutes a unique example of selective injury to atrial myocardium.
  • |Acute Disease[MESH]
  • |Animals[MESH]
  • |Cardiomyopathies/chemically induced/*pathology/physiopathology[MESH]
  • |Cattle[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Female[MESH]
  • |Furans/*toxicity[MESH]
  • |Heart Atria/drug effects/pathology/ultrastructure[MESH]
  • |Macrophages/pathology/ultrastructure[MESH]
  • |Male[MESH]
  • |Monensin/*toxicity[MESH]
  • |Myocardial Contraction/drug effects[MESH]
  • |Myocardium/pathology/*ultrastructure[MESH]
  • |Necrosis[MESH]


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