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Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats #MMPMID6640198
Devane J; Ryan MP
Br J Pharmacol 1983[Nov]; 80 (3): 421-8 PMID6640198show ga
The effects of the potassium-sparing diuretic, amiloride, on fractional magnesium excretion were investigated at four doses (0.02, 0.08, 0.20 and 2.00 mg kg-1 h-1) during frusemide-induced diuresis. Amiloride caused a dose-dependent reduction in the fractional excretion of both magnesium and potassium, whereas the effects of amiloride, over the same dose range, on fractional sodium and calcium excretion were not dose-dependent. The results indicate that amiloride exerted a specific renal action to alter magnesium and potassium transport dissociated from effects on sodium excretion.