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10.1111/j.1476-5381.1983.tb10711.x

http://scihub22266oqcxt.onion/10.1111/j.1476-5381.1983.tb10711.x
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suck abstract from ncbi

pmid6640198      Br+J+Pharmacol 1983 ; 80 (3): 421-8
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  • Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats #MMPMID6640198
  • Devane J; Ryan MP
  • Br J Pharmacol 1983[Nov]; 80 (3): 421-8 PMID6640198show ga
  • The effects of the potassium-sparing diuretic, amiloride, on fractional magnesium excretion were investigated at four doses (0.02, 0.08, 0.20 and 2.00 mg kg-1 h-1) during frusemide-induced diuresis. Amiloride caused a dose-dependent reduction in the fractional excretion of both magnesium and potassium, whereas the effects of amiloride, over the same dose range, on fractional sodium and calcium excretion were not dose-dependent. The results indicate that amiloride exerted a specific renal action to alter magnesium and potassium transport dissociated from effects on sodium excretion.
  • |Amiloride/*pharmacology[MESH]
  • |Animals[MESH]
  • |Calcium/metabolism[MESH]
  • |Diuresis/*drug effects[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Furosemide/*pharmacology[MESH]
  • |Kidney/*metabolism[MESH]
  • |Magnesium/*metabolism[MESH]
  • |Male[MESH]
  • |Potassium/metabolism[MESH]
  • |Pyrazines/*pharmacology[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Strains[MESH]


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