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10.1073/pnas.81.20.6511 http://scihub22266oqcxt.onion/10.1073/pnas.81.20.6511 6593713!391954!6593713     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 1984 ; 81 (20): 6511-5 Nephropedia Template TP {{tp|p=6593713|t=1984. Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations |pdf=|usr=}}{{6593713}} gab.com Text Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=6593713 #FOAvip Intracellular levels of free Mg2+ in human erythrocytes were determined by 31P NMR spectroscopy in 26 fasted subjects and were correlated with blood pressures and serum levels of total magnesium (bound and free Mg2+) and ionized calcium from the same subjects in a seated position. Untreated hypertensive individuals consistently demonstrated lower levels of intracellular free magnesium (192 +/- 8 microM, n = 11) than either normotensive (261 +/- 9.8 microM, n = 7, P less than 0.001 vs. untreated hypertensive subjects) or hypertensive subjects whose blood pressure had been normalized on therapy (237 +/- 7.8 microM, n = 8, P less than 0.005 vs. untreated hypertensives). For all subjects, strong relationships existed between intracellular free magnesium and diastolic blood pressure (r = -0.85, P less than 0.001) and systolic blood pressure (r = -0.71, P less than 0.001). Significant relationships also were observed between intracellular free magnesium levels and extracellular serum levels of calcium ion (r = -0.77, P less than 0.001) as well as serum concentrations of total magnesium (r = 0.62, P less than 0.001). We conclude that significant depletion of intracellular free magnesium levels are apparent in erythrocytes of subjects with essential hypertension. Furthermore, the close, inverse relationship of free magnesium levels with the height of the blood pressure suggests that abnormalities of intracellular magnesium metabolism may contribute to the pathophysiology of human essential hypertension. Twit Text FOAVip Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=6593713 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6593713 #FOAvip English Wikipedia <ref>{{Cite pmid|6593713}}</ref> Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations #MMPMID6593713 Resnick LM; Gupta RK; Laragh JH Proc Natl Acad Sci U S A 1984[Oct]; 81 (20): 6511-5 PMID6593713show ga Intracellular levels of free Mg2+ in human erythrocytes were determined by 31P NMR spectroscopy in 26 fasted subjects and were correlated with blood pressures and serum levels of total magnesium (bound and free Mg2+) and ionized calcium from the same subjects in a seated position. Untreated hypertensive individuals consistently demonstrated lower levels of intracellular free magnesium (192 +/- 8 microM, n = 11) than either normotensive (261 +/- 9.8 microM, n = 7, P less than 0.001 vs. untreated hypertensive subjects) or hypertensive subjects whose blood pressure had been normalized on therapy (237 +/- 7.8 microM, n = 8, P less than 0.005 vs. untreated hypertensives). For all subjects, strong relationships existed between intracellular free magnesium and diastolic blood pressure (r = -0.85, P less than 0.001) and systolic blood pressure (r = -0.71, P less than 0.001). Significant relationships also were observed between intracellular free magnesium levels and extracellular serum levels of calcium ion (r = -0.77, P less than 0.001) as well as serum concentrations of total magnesium (r = 0.62, P less than 0.001). We conclude that significant depletion of intracellular free magnesium levels are apparent in erythrocytes of subjects with essential hypertension. Furthermore, the close, inverse relationship of free magnesium levels with the height of the blood pressure suggests that abnormalities of intracellular magnesium metabolism may contribute to the pathophysiology of human essential hypertension. |Blood Pressure[MESH] |Calcium/blood[MESH] |Cations, Divalent/blood[MESH] |Erythrocytes/metabolism[MESH] |Humans[MESH] |Hypertension/*blood[MESH] |Magnesium/*blood[MESH]Intracellular free magnesium in erythrocytes of essential hypertension(epmc).pdf DeepDyve Pubget Overpricing