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10.1152/ajprenal.1984.247.5.F746 http://scihub22266oqcxt.onion/10.1152/ajprenal.1984.247.5.F746 6548610!ä!6548610 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol 1984 ; 247 (5 Pt 2): F746-52 Nephropedia Template TP {{tp|p=6548610|t=1984. Mechanism of chronic hypocalciuria with chlorthalidone: reduced calcium absorption |pdf=|usr=}}{{6548610}} gab.com Text Mechanism of chronic hypocalciuria with chlorthalidone: reduced calcium absorption JO: Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=6548610 #FOAvip Chlorthalidone, like other benzothiadiazides, lowers urine calcium excretion chronically. If intestinal calcium absorption did not fall or bone accretion did not increase, serum calcium and the filtered load of calcium would increase and urine calcium would return to pretreatment levels. To determine whether overall intestinal calcium absorption fell, we fed chlorthalidone (5 mg X kg body wt-1 X 24 h-1) to 10 adult male rats eating 15 g/day of a 0.6% calcium diet. Compared with 10 control rats, chlorthalidone reduced urine calcium [2.1 +/- 0.1 (SE) vs. 5.8 +/- 0.5 mg/6 days; P less than 0.001]. Fecal calcium rose (307 +/- 9 vs. 257 +/- 12; P less than 0.005) because percent intestinal calcium absorption fell (41 +/- 2 vs. 52 +/- 2; P less than 0.002). Twenty other rats given the same diet were injected subcutaneously with 1,25(OH)2D3 (50 ng/day). In these rats, chlorthalidone reduced urine calcium (23 +/- 3 vs. 59 +/- 3; P less than 0.001) and percent intestinal calcium absorption (60 +/- 1 vs. 66 +/- 1; P less than 0.01). With or without 1,25(OH)2D3, chronic administration of chlorthalidone reduces intestinal calcium absorption, and this reduction seems to be the mechanism that permits urine calcium excretion to remain low. Twit Text FOAVip Mechanism of chronic hypocalciuria with chlorthalidone: reduced calcium absorption ????Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=6548610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6548610 #FOAvip English Wikipedia <ref>{{Cite pmid|6548610}}</ref> Mechanism of chronic hypocalciuria with chlorthalidone: reduced calcium absorption #MMPMID6548610 Bushinsky DA; Favus MJ; Coe FL Am J Physiol 1984[Nov]; 247 (5 Pt 2): F746-52 PMID6548610show ga Chlorthalidone, like other benzothiadiazides, lowers urine calcium excretion chronically. If intestinal calcium absorption did not fall or bone accretion did not increase, serum calcium and the filtered load of calcium would increase and urine calcium would return to pretreatment levels. To determine whether overall intestinal calcium absorption fell, we fed chlorthalidone (5 mg X kg body wt-1 X 24 h-1) to 10 adult male rats eating 15 g/day of a 0.6% calcium diet. Compared with 10 control rats, chlorthalidone reduced urine calcium [2.1 +/- 0.1 (SE) vs. 5.8 +/- 0.5 mg/6 days; P less than 0.001]. Fecal calcium rose (307 +/- 9 vs. 257 +/- 12; P less than 0.005) because percent intestinal calcium absorption fell (41 +/- 2 vs. 52 +/- 2; P less than 0.002). Twenty other rats given the same diet were injected subcutaneously with 1,25(OH)2D3 (50 ng/day). In these rats, chlorthalidone reduced urine calcium (23 +/- 3 vs. 59 +/- 3; P less than 0.001) and percent intestinal calcium absorption (60 +/- 1 vs. 66 +/- 1; P less than 0.01). With or without 1,25(OH)2D3, chronic administration of chlorthalidone reduces intestinal calcium absorption, and this reduction seems to be the mechanism that permits urine calcium excretion to remain low. |Animals[MESH] |Bone and Bones/metabolism[MESH] |Calcitriol/pharmacology[MESH] |Calcium, Dietary/administration & dosage[MESH] |Calcium/metabolism/*urine[MESH] |Chlorthalidone/*pharmacology[MESH] |Intestinal Absorption/*drug effects[MESH] |Magnesium/metabolism[MESH] |Male[MESH] |Phosphorus/metabolism[MESH]Mechanism of chronic hypocalciuria with chlorthalidone: reduced calciu(epmc).pdf DeepDyve Pubget Overpricing