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The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat |pdf=|usr=}}{{6450254}} gab.com Text The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat JO: J Lab Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=6450254 #FOAvip Diabetes mellitus was induced in Lewis rats by streptozotocin, and these animals and control rats fed ad lib were studied after 7 weeks. At the time of sacrifice, nondecalcified histological sections of bone were prepared and subsequently quantitated by micromorphometric techniques. In addition, tibial alkaline phosphatase and mineral ash content were determined. The bones obtained from the diabetic animals are characterized by significant decrements in the quantities of osteoid and osteoclasts and by failure to acquire a tetracycline label. These histological features are attended by reduced quantities of urinary hydroxyproline and tibial alkaline phosphatase. As compared with control animals fed ad lib, diabetic rats are hyperphosphatemic and markedly hypercalciuric. Circulating alkaline phosphatase is also elevated and associated with a parallel increase in intestinal content of this enzyme. Although serum corticosterone levels are increased, diabetes is associated with decrements in both circulating immunoreactive parathyroid hormone and 1,25(OH)2D. We conclude that prolonged streptozotocin-induced diabetes mellitus in the rat results in reduced bone turnover. The relative roles that functional caloric deprivation, low circulating levels of 1,25(OH)2D, hypercalciuria, hypercortisolemia, and decreased blood parathyroid hormone levels play in the genesis of these skeletal abnormalities remain to be determined. Twit Text FOAVip The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat ????J Lab Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=6450254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6450254 #FOAvip English Wikipedia <ref>{{Cite pmid|6450254}}</ref> The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat #MMPMID6450254 Shires R; Teitelbaum SL; Bergfeld MA; Fallon MD; Slatopolsky E; Avioli LV J Lab Clin Med 1981[Feb]; 97 (2): 231-40 PMID6450254show ga Diabetes mellitus was induced in Lewis rats by streptozotocin, and these animals and control rats fed ad lib were studied after 7 weeks. At the time of sacrifice, nondecalcified histological sections of bone were prepared and subsequently quantitated by micromorphometric techniques. In addition, tibial alkaline phosphatase and mineral ash content were determined. The bones obtained from the diabetic animals are characterized by significant decrements in the quantities of osteoid and osteoclasts and by failure to acquire a tetracycline label. These histological features are attended by reduced quantities of urinary hydroxyproline and tibial alkaline phosphatase. As compared with control animals fed ad lib, diabetic rats are hyperphosphatemic and markedly hypercalciuric. Circulating alkaline phosphatase is also elevated and associated with a parallel increase in intestinal content of this enzyme. Although serum corticosterone levels are increased, diabetes is associated with decrements in both circulating immunoreactive parathyroid hormone and 1,25(OH)2D. We conclude that prolonged streptozotocin-induced diabetes mellitus in the rat results in reduced bone turnover. The relative roles that functional caloric deprivation, low circulating levels of 1,25(OH)2D, hypercalciuria, hypercortisolemia, and decreased blood parathyroid hormone levels play in the genesis of these skeletal abnormalities remain to be determined. |Alkaline Phosphatase/metabolism[MESH] |Animals[MESH] |Bone and Bones/*metabolism[MESH] |Calcium/metabolism[MESH] |Diabetes Mellitus, Experimental/*metabolism/pathology[MESH] |Homeostasis[MESH] |Hydrogen-Ion Concentration[MESH] |Magnesium/metabolism[MESH] |Male[MESH] |Phosphates/metabolism[MESH] |Potassium/metabolism[MESH] |Rats[MESH] |Sodium/metabolism[MESH]The effect of streptozotocin-induced chronic diabetes mellitus on bone(epmc).pdf DeepDyve Pubget Overpricing