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10.1111/j.1365-3083.1984.tb00943.x

http://scihub22266oqcxt.onion/10.1111/j.1365-3083.1984.tb00943.x
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6427919!ä!6427919

suck abstract from ncbi


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pmid6427919      Scand+J+Immunol 1984 ; 19 (4): 365-71
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  • Alloreactive cytotoxic T lymphocytes lyse syngeneic influenza-infected tumour cell targets #MMPMID6427919
  • Mullbacher A; Ashman RB; Ada GL
  • Scand J Immunol 1984[Apr]; 19 (4): 365-71 PMID6427919show ga
  • Spleen cells from C57BL/10(H-2b) mice, when stimulated in vitro to Kk alloantigens, lysed syngeneic influenza A virus-infected tumour cell targets but not uninfected or vaccinia- or Sendai virus-infected targets. Peritoneal macrophage targets infected with influenza virus were not lysed. Lysis of H-2k targets and EL4-A influenza virus-infected targets was abrogated by treatment of effectors with anti-Thy 1.2 plus C and anti-Lyt 2 plus C but not by anti-Lyt 1 plus C or anti-GM-1, a natural killer cell-specific, monoclonal antibody plus C. Cold target inhibition experiments indicated that one and the same population of Tc cells see H-2Kk and H-2b plus influenza virus. Sensitization of C57BL/10 mice to Kk in vivo did not potentiate virus clearance from lungs. The data are discussed in relation to observed Ir gene effects and variation and modulation of H-2 antigens on tumour cells.
  • |Animals[MESH]
  • |Cross Reactions[MESH]
  • |Genes, MHC Class II[MESH]
  • |H-2 Antigens/*immunology[MESH]
  • |Immunization[MESH]
  • |Influenza A virus/*immunology[MESH]
  • |Mice[MESH]
  • |Orthomyxoviridae Infections/immunology[MESH]


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