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10.1002/path.1711420112 http://scihub22266oqcxt.onion/10.1002/path.1711420112 6422024!ä!6422024 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pathol 1984 ; 142 (1): 67-77 Nephropedia Template TP {{tp|p=6422024|t=1984. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis |pdf=|usr=}}{{6422024}} gab.com Text Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=6422024 #FOAvip In glucocorticoid-treated rat thymocytes and the murine lymphoid cell lines L5178 and S49 the morphology of apoptosis is associated with chromatin cleavage. The cleavage is at internucleosomal sites, apparently through activation of an endogenous endonuclease. In variants of the cell lines selected for resistance to glucocorticoid, neither apoptosis nor chromatin cleavage were observed after steroid treatment, and steroid receptors were undetectable. In thymocytes, both the morphological changes of apoptosis and chromatin cleavage were inhibited by cycloheximide and actinomycin D. The calcium-magnesium ionophore A23187 induced apoptosis and chromatin cleavage in thymocytes, and these effects were also inhibited by cycloheximide. The data confirm that the condensed chromatin which characterizes apoptosis morphologically consists of endogenously digested chromatin fragments. They also provide support for the view that at least some cells enter apoptosis by a process dependent upon macromolecular synthesis. Twit Text FOAVip Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=6422024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6422024 #FOAvip English Wikipedia <ref>{{Cite pmid|6422024}}</ref> Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis #MMPMID6422024 Wyllie AH; Morris RG; Smith AL; Dunlop D J Pathol 1984[Jan]; 142 (1): 67-77 PMID6422024show ga In glucocorticoid-treated rat thymocytes and the murine lymphoid cell lines L5178 and S49 the morphology of apoptosis is associated with chromatin cleavage. The cleavage is at internucleosomal sites, apparently through activation of an endogenous endonuclease. In variants of the cell lines selected for resistance to glucocorticoid, neither apoptosis nor chromatin cleavage were observed after steroid treatment, and steroid receptors were undetectable. In thymocytes, both the morphological changes of apoptosis and chromatin cleavage were inhibited by cycloheximide and actinomycin D. The calcium-magnesium ionophore A23187 induced apoptosis and chromatin cleavage in thymocytes, and these effects were also inhibited by cycloheximide. The data confirm that the condensed chromatin which characterizes apoptosis morphologically consists of endogenously digested chromatin fragments. They also provide support for the view that at least some cells enter apoptosis by a process dependent upon macromolecular synthesis. |*Cell Survival/drug effects[MESH] |Animals[MESH] |Calcimycin/pharmacology[MESH] |Cell Line[MESH] |Chromatin/*physiology/ultrastructure[MESH] |Cycloheximide/pharmacology[MESH] |Dactinomycin/pharmacology[MESH] |Female[MESH] |Leukemia, Experimental/pathology[MESH] |Macromolecular Substances[MESH] |Male[MESH] |Methylprednisolone Hemisuccinate/pharmacology[MESH] |Mice[MESH] |Microscopy, Electron[MESH] |Rats[MESH] |Rats, Inbred Strains[MESH] |T-Lymphocytes/drug effects/ultrastructure[MESH]Chromatin cleavage in apoptosis: association with condensed chromatin (epmc).pdf DeepDyve Pubget Overpricing