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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 S+Afr+Med+J 1984 ; 66 (18): 680-1 Nephropedia Template TP
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Effects of hydrochlorothiazide plus sotalol on acute urinary electrolyte excretion in normal subjects #MMPMID6387965
Leary WP; Reyes AJ; van der Byl K
S Afr Med J 1984[Nov]; 66 (18): 680-1 PMID6387965show ga
Twenty-four-hour urinary outputs, total volume and urinary chlorine (Cl), sodium (Na), potassium (K), calcium, magnesium (Mg), total inorganic phosphate and creatinine levels were measured in 12 biologically equivalent healthy volunteers given single oral doses of placebo, hydrochlorothiazide (HCTZ) 50 mg and a combination of HCTZ and sotalol (STL) 320 mg in a double-blind, random study. HCTZ and HCTZ + STL increased urinary volume and Na, K, Cl, phosphate and Mg levels significantly and to a similar extent. Since HCTZ causes hyperkaliuresis and hypermagnesiuresis with or without simultaneous administration of STL, the latter does not change the acute effects of HCTZ in healthy subjects.