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6278936S-100proteininsoft-tissuetumorsderivedfromSchwanncellsandmelanocytes.!1916175!6278936; 100
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suck abstract from ncbi


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pmid6278936; 100      Am+J+Pathol;+Birth+Defects+Orig+Artic+Ser 1982 ; 106; 11 (2; 6): 261-8; 273-8
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  • S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes ; Bovine mannosidosis--a model lysosomal storage disease #MMPMID6278936; 100
  • Stefansson K; Wollmann R; Jerkovic M; Jolly RD; Thompson KG; Winchester BG
  • Am J Pathol; Birth Defects Orig Artic Ser 1982[Feb]; 106; 11 (2; 6): 261-8; 273-8 PMID6278936; 100show ga
  • In soft tissues outside the central nervous system, S-100 protein is found normally only in Schwann cells. Using the peroxidase-antiperoxidase immunohistochemical method S-100 was also found in tumors derived from Schwann cells and melanocytes, including neurofibromas, neurilemomas, granular cell myoblastomas, cutaneous nevi, and malignant melanomas. S-100 was not detected in malignant Schwannomas, neuroblastomas, oat cell carcinomas, medullary carcinomas of the thyroid, paragangliomas, or meningiomas. S-100 was also absent from neoplasms of soft tissues not usually considered to arise from cells of neural crest origin. S-100 appears to be a useful marker for identifying neoplasms derived from Schwann cells and melanocytes.
  • |*Cattle Diseases/blood/enzymology/genetics[MESH]
  • |*Disease Models, Animal[MESH]
  • |Animals[MESH]
  • |Blood[MESH]
  • |Carbohydrate Metabolism, Inborn Errors/blood/enzymology/genetics/*veterinary[MESH]
  • |Cattle[MESH]
  • |Heterozygote[MESH]
  • |Histocytochemistry[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Immunoenzyme Techniques[MESH]
  • |Lymphocytes/enzymology[MESH]
  • |Lysosomes/enzymology/*metabolism[MESH]
  • |Mannose/*metabolism[MESH]
  • |Mannosidases/blood/deficiency[MESH]
  • |Melanocytes/*analysis[MESH]
  • |Melanoma/analysis/pathology[MESH]
  • |Neoplasm Proteins/analysis[MESH]
  • |Neoplasms, Muscle Tissue/analysis/pathology[MESH]
  • |Nerve Tissue Proteins/*analysis[MESH]
  • |Neurilemmoma/analysis/pathology[MESH]
  • |Neuroblastoma/analysis/pathology[MESH]
  • |Neuroma, Acoustic/analysis/pathology[MESH]
  • |Nevus/analysis/pathology[MESH]
  • |Rhabdomyosarcoma/analysis/pathology[MESH]
  • |S100 Proteins/*analysis[MESH]
  • |Schwann Cells/*analysis[MESH]
  • |Skin Neoplasms/analysis/pathology[MESH]


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