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pmid6278936      Am+J+Pathol 1982 ; 106 (2): 261-8
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  • S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes #MMPMID6278936
  • Stefansson K; Wollmann R; Jerkovic M
  • Am J Pathol 1982[Feb]; 106 (2): 261-8 PMID6278936show ga
  • In soft tissues outside the central nervous system, S-100 protein is found normally only in Schwann cells. Using the peroxidase-antiperoxidase immunohistochemical method S-100 was also found in tumors derived from Schwann cells and melanocytes, including neurofibromas, neurilemomas, granular cell myoblastomas, cutaneous nevi, and malignant melanomas. S-100 was not detected in malignant Schwannomas, neuroblastomas, oat cell carcinomas, medullary carcinomas of the thyroid, paragangliomas, or meningiomas. S-100 was also absent from neoplasms of soft tissues not usually considered to arise from cells of neural crest origin. S-100 appears to be a useful marker for identifying neoplasms derived from Schwann cells and melanocytes.
  • |Histocytochemistry[MESH]
  • |Humans[MESH]
  • |Immunoenzyme Techniques[MESH]
  • |Melanocytes/*analysis[MESH]
  • |Melanoma/analysis/pathology[MESH]
  • |Neoplasm Proteins/analysis[MESH]
  • |Neoplasms, Muscle Tissue/analysis/pathology[MESH]
  • |Nerve Tissue Proteins/*analysis[MESH]
  • |Neurilemmoma/analysis/pathology[MESH]
  • |Neuroblastoma/analysis/pathology[MESH]
  • |Neuroma, Acoustic/analysis/pathology[MESH]
  • |Nevus/analysis/pathology[MESH]
  • |Rhabdomyosarcoma/analysis/pathology[MESH]
  • |S100 Proteins/*analysis[MESH]
  • |Schwann Cells/*analysis[MESH]
  • |Skin Neoplasms/analysis/pathology[MESH]


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