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10.1111/j.1365-2125.1982.tb01911.x http://scihub22266oqcxt.onion/10.1111/j.1365-2125.1982.tb01911.x 6125170!1402185!6125170     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 1982 ; 13 (Suppl 2): 199S-200S Nephropedia Template TP {{tp|p=6125170|t=1982. Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs |pdf=|usr=}}{{6125170}} gab.com Text Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=6125170 #FOAvip 1 The heart rate responses to increasing doses of isoprenaline (n = 6) (during infusion with atropine 0.5 mg/min i.v.) and noradrenaline (n = 5), (during infusion with phentolamine 160 mg/h i.v.) were recorded before and after the intravenous administration of propranolol (15 mg) or metoprolol (15 mg). 2 In the doses used, metoprolol was less potent than propranolol in antagonizing isoprenaline-induced tachycardia, during atropine infusion. 3 In volunteers treated with phentolamine both metoprolol and propranolol produced similar inhibition of noradrenaline-induced tachycardia, indicating comparable beta 1-adrenoceptor blockade in the doses used. 4 The fact that the shift of the dose-response curve of isoprenaline-induced tachycardia was smaller after metoprolol than after propranolol supports the hypothesis that beta 2-adrenoceptors are present in the heart. Twit Text FOAVip Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=6125170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6125170 #FOAvip English Wikipedia <ref>{{Cite pmid|6125170}}</ref> Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs #MMPMID6125170 Bonelli J Br J Clin Pharmacol 1982[]; 13 (Suppl 2): 199S-200S PMID6125170show ga 1 The heart rate responses to increasing doses of isoprenaline (n = 6) (during infusion with atropine 0.5 mg/min i.v.) and noradrenaline (n = 5), (during infusion with phentolamine 160 mg/h i.v.) were recorded before and after the intravenous administration of propranolol (15 mg) or metoprolol (15 mg). 2 In the doses used, metoprolol was less potent than propranolol in antagonizing isoprenaline-induced tachycardia, during atropine infusion. 3 In volunteers treated with phentolamine both metoprolol and propranolol produced similar inhibition of noradrenaline-induced tachycardia, indicating comparable beta 1-adrenoceptor blockade in the doses used. 4 The fact that the shift of the dose-response curve of isoprenaline-induced tachycardia was smaller after metoprolol than after propranolol supports the hypothesis that beta 2-adrenoceptors are present in the heart. |Adrenergic beta-Antagonists/*pharmacology[MESH] |Adult[MESH] |Atropine/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Heart Rate/drug effects[MESH] |Humans[MESH] |Isoproterenol/pharmacology[MESH] |Male[MESH] |Metoprolol/pharmacology[MESH] |Norepinephrine/pharmacology[MESH] |Organ Specificity[MESH]Relevance of selectivity and non-selectivity in beta-adrenoceptor bloc(epmc).pdf DeepDyve Pubget Overpricing