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10.1097/00000658-197102000-00014

http://scihub22266oqcxt.onion/10.1097/00000658-197102000-00014
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5100098Sweatglandcarcinoma:aclinico-pathologicstudyof83patients.!1397621!5100098; 83
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suck abstract from ncbi


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pmid5100098; 83      Ann+Surg;+Biochim+Biophys+Acta 1971 ; 173; 412 (2; 2): 270-4; 197-201
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  • Sweat gland carcinoma: a clinico-pathologic study of 83 patients ; Mechanical precipitation of hemoglobin koln #MMPMID5100098; 83
  • el-Domeiri AA; Brasfield RD; Huvos AG; Strong EW; Asakura T; Adachi K; Shapiro M; Friedman S; Schwartz E
  • Ann Surg; Biochim Biophys Acta 1971[Feb]; 173; 412 (2; 2): 270-4; 197-201 PMID5100098; 83show ga
  • Hb Koln (beta 98 Val leads to Met) was found to precipitate rapidly during mechanical shaking. The rate of precipitation of Hb Koln is 5-6 times faster than that of Hb S. The kinetics of precipitation of the patient's hemolysate, which is a mixture of Hb Koln and Hb A, showed a biphasic curve indicating that Hb Koln precipitates independently from Hb A. The instability of Hb Koln may be attributed to the conformational change in the vicinity of heme. The mechanical shaking may be used as a new method for detection and quantitation of hemoglobin Koln and other unstable hemoglobins.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Chemical Precipitation[MESH]
  • |Child[MESH]
  • |Germany, West[MESH]
  • |Hemoglobin, Sickle/isolation & purification[MESH]
  • |Hemoglobins, Abnormal/*isolation & purification[MESH]
  • |Humans[MESH]
  • |Hydrogen-Ion Concentration[MESH]
  • |Methionine[MESH]
  • |Osmolar Concentration[MESH]
  • |Temperature[MESH]


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