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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ann+Microbiol+(Paris) 1979 ; 130 A (1): 119-32 Nephropedia Template TP
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Interactions entre le virus grippal et le macrophage alveolaire de souris: etude in vitro #MMPMID475216
Lemercier G; Mavet S; Burckhart MF; Fontanges R
Ann Microbiol (Paris) 1979[Jan]; 130 A (1): 119-32 PMID475216show ga
Interactions between influenza virus A/PR/8/34 (H0N1) and Balb/c mouse lung alveolar macrophages have been studied in vitro. One day after initiation of alveolar macrophage culture in 35 mm Falcon dishes, the virus suspension was allowed to adsorb to the cells for 1 h. Detachment of cells from the plastic substrate, morphological changes in adherent cells and decreased phagocytosis of heat-killed Candida albicans occured slowly as compared to control cultures. These facts appeared to be directly correlated to the concentration of viruses in the inoculum. Data yielded by virus titrations, electron microscopy and immunofluorescence suggest that mouse lung alveolar macrophages are able to take up a large amount of viral particles and inhibit their replication, allowing only an abortive viral cycle.