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10.1152/ajplegacy.1973.224.3.651 http://scihub22266oqcxt.onion/10.1152/ajplegacy.1973.224.3.651 4691282!2964146!4691282     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol 1973 ; 224 (3): 651-8 Nephropedia Template TP {{tp|p=4691282|t=1973. Acute effect of prednisolone on renal handling of sodium |pdf=|usr=}}{{4691282}} gab.com Text Acute effect of prednisolone on renal handling of sodium JO: Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=4691282 #FOAvip The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB). Prednisolone, 0.25 mg/100 g per hr, was infused directly into left renal artery and urine was collected separately from each kidney. Predominantly unilateral increases in urine flow (V) and Na excretion were noticed in all experiments during prednisolone infusion. In the hydropenic rats the maximal increments on the infused side were, for V (mean +/- SD), from 9.3 +/- 1.5 to 21.4 +/- 0.8 mul/min (P < 0.001); for C(Na)/C(In), from 0.28 +/- 0.11 to 2.97 +/- 0.71 % (P < 0.005); and for TH2Oc/CIn, from 2.93 +/- 2.26 to 5.32 +/- 1.92% (P < 0.05). In the rats with water diuresis, the maximal increases were, for V/C(In), from 5.87 +/- 1.97 to 10.1 +/- 6.0% (P < 0.005); for C(H(2)O)/C(In), from 4.09 +/- 0.68 to 6.00 +/- 0.44% (P < 0.0005); and for C(Na)/C(In), from 0.22 +/- 0.07 to 0.70 +/- 0.38% (P < 0.01). In DTB-rats the maximal increases were for V from 48.6 +/- 9.0 to 72.7 +/- 14.1 mul/min (P < 0.0005) and for C(Na)/C(In) from 9.42 +/- 2.97 to 20.23 +/- 7.34% (P < 0.005). In the contralateral kidney these changes were less pronounced. These observations suggest that prednisolone depresses directly Na reabsorption. The association of natriuresis with augmented TH2Oc/CIn and C(H(2)O)/C(In) during hydropenia and water diuresis, respectively, and the increases in V and C(Na)/C(In) during DTB, all are consistent with inhibition of Na reabsorption in the proximal tubule. Twit Text FOAVip Acute effect of prednisolone on renal handling of sodium ????Am J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=4691282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=4691282 #FOAvip English Wikipedia <ref>{{Cite pmid|4691282}}</ref> Acute effect of prednisolone on renal handling of sodium #MMPMID4691282 Popovtzer MM; Robinette J; Halgrimson CG; Starzl TE Am J Physiol 1973[Mar]; 224 (3): 651-8 PMID4691282show ga The effect of prednisolone on renal handling of sodium (Na) was studied in rats under three experimental conditions: 1) hydropenia, 2) water diuresis, and 3) distal tubular blockade (DTB). Prednisolone, 0.25 mg/100 g per hr, was infused directly into left renal artery and urine was collected separately from each kidney. Predominantly unilateral increases in urine flow (V) and Na excretion were noticed in all experiments during prednisolone infusion. In the hydropenic rats the maximal increments on the infused side were, for V (mean +/- SD), from 9.3 +/- 1.5 to 21.4 +/- 0.8 mul/min (P < 0.001); for C(Na)/C(In), from 0.28 +/- 0.11 to 2.97 +/- 0.71 % (P < 0.005); and for TH2Oc/CIn, from 2.93 +/- 2.26 to 5.32 +/- 1.92% (P < 0.05). In the rats with water diuresis, the maximal increases were, for V/C(In), from 5.87 +/- 1.97 to 10.1 +/- 6.0% (P < 0.005); for C(H(2)O)/C(In), from 4.09 +/- 0.68 to 6.00 +/- 0.44% (P < 0.0005); and for C(Na)/C(In), from 0.22 +/- 0.07 to 0.70 +/- 0.38% (P < 0.01). In DTB-rats the maximal increases were for V from 48.6 +/- 9.0 to 72.7 +/- 14.1 mul/min (P < 0.0005) and for C(Na)/C(In) from 9.42 +/- 2.97 to 20.23 +/- 7.34% (P < 0.005). In the contralateral kidney these changes were less pronounced. These observations suggest that prednisolone depresses directly Na reabsorption. The association of natriuresis with augmented TH2Oc/CIn and C(H(2)O)/C(In) during hydropenia and water diuresis, respectively, and the increases in V and C(Na)/C(In) during DTB, all are consistent with inhibition of Na reabsorption in the proximal tubule. |Animals[MESH] |Female[MESH] |Kidney Tubules, Proximal/drug effects[MESH] |Kidney/*drug effects[MESH] |Natriuresis/*drug effects[MESH] |Prednisolone/*pharmacology[MESH] |Rats[MESH] |Sodium Chloride[MESH] |Stimulation, Chemical[MESH]Acute effect of prednisolone on renal handling of sodium (epmc).pdf DeepDyve Pubget Overpricing