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10.1172/JCI106990 http://scihub22266oqcxt.onion/10.1172/JCI106990 4338123!292336!4338123     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 1972 ; 51 (7): 1879-88 Nephropedia Template TP {{tp|p=4338123|t=1972. The interactions of thiazide diuretics with parathyroid hormone and vitamin D Studies in patients with hypoparathyroidism |pdf=|usr=}}{{4338123}} gab.com Text The interactions of thiazide diuretics with parathyroid hormone and vitamin D Studies in patients with hypoparathyroidism JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=4338123 #FOAvip In order to clarify the mechanisms of thiazide diuretic-induced hypocalciuria, the effect of a thiazide was studied for 7 days in seven patients with hypoparathyroidism on Vitamin D and one on calcium infusion, and seven euparathyroid patients with hypercalciuria. In the control group, calcium excretion (mg/24 hr) fell by 44% from 415 to 232 within 4 days and remained at this level. Plasma total calcium corrected for total protein did not change. In the hypoparathyroid group, calcium excretion fell by 11% from 351 to 311 and then returned to the base line level. Plasma total calcium (mg/100 ml) increased from 10.09 to 10.88, 11.29 and 10.77 at the end of the 2nd, 4th, and 7th day of thiazide administration. In the patient having i.v. calcium and no Vitamin D, neither plasma nor urinary calcium changed significantly. In both groups sodium excretion increased on the first 2 days and fell to or below base line level thereafter. Urinary phosphate, magnesium, and potassium increased, plasma phosphate rose, and magnesium and potassium fell. It is concluded that: (a) The hypocalciuric effect of thiazides requires the presence of parathyroid hormone and is not solely a result of sodium depletion. (b) The hypercalcemic effect of thiazides in hypoparathyroidism is due to increased release of calcium from bone and requires the presence of a pharmacologic dose of Vitamin D. (c) Thiazides enhane the action of parathyroid hormone on bone and kidney; Vitamin D can replace parathyroid hormone in this interaction in bone but not in kidney. Twit Text FOAVip The interactions of thiazide diuretics with parathyroid hormone and vitamin D Studies in patients with hypoparathyroidism ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=4338123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=4338123 #FOAvip English Wikipedia <ref>{{Cite pmid|4338123}}</ref> The interactions of thiazide diuretics with parathyroid hormone and vitamin D Studies in patients with hypoparathyroidism #MMPMID4338123 Parfitt AM J Clin Invest 1972[Jul]; 51 (7): 1879-88 PMID4338123show ga In order to clarify the mechanisms of thiazide diuretic-induced hypocalciuria, the effect of a thiazide was studied for 7 days in seven patients with hypoparathyroidism on Vitamin D and one on calcium infusion, and seven euparathyroid patients with hypercalciuria. In the control group, calcium excretion (mg/24 hr) fell by 44% from 415 to 232 within 4 days and remained at this level. Plasma total calcium corrected for total protein did not change. In the hypoparathyroid group, calcium excretion fell by 11% from 351 to 311 and then returned to the base line level. Plasma total calcium (mg/100 ml) increased from 10.09 to 10.88, 11.29 and 10.77 at the end of the 2nd, 4th, and 7th day of thiazide administration. In the patient having i.v. calcium and no Vitamin D, neither plasma nor urinary calcium changed significantly. In both groups sodium excretion increased on the first 2 days and fell to or below base line level thereafter. Urinary phosphate, magnesium, and potassium increased, plasma phosphate rose, and magnesium and potassium fell. It is concluded that: (a) The hypocalciuric effect of thiazides requires the presence of parathyroid hormone and is not solely a result of sodium depletion. (b) The hypercalcemic effect of thiazides in hypoparathyroidism is due to increased release of calcium from bone and requires the presence of a pharmacologic dose of Vitamin D. (c) Thiazides enhane the action of parathyroid hormone on bone and kidney; Vitamin D can replace parathyroid hormone in this interaction in bone but not in kidney. |*Drug Interactions[MESH] |Adult[MESH] |Aged[MESH] |Bone and Bones/drug effects[MESH] |Calcium/blood/metabolism/urine[MESH] |Chlorothiazide/*pharmacology[MESH] |Cholecalciferol/therapeutic use[MESH] |Clinical Trials as Topic[MESH] |Dihydrotachysterol/therapeutic use[MESH] |Ergocalciferols/therapeutic use[MESH] |Female[MESH] |Humans[MESH] |Hypoparathyroidism/*drug therapy[MESH] |Kidney Tubules/drug effects[MESH] |Magnesium/urine[MESH] |Male[MESH] |Methyclothiazide/*pharmacology[MESH] |Middle Aged[MESH] |Natriuresis[MESH] |Parathyroid Hormone/physiology[MESH] |Phosphates/blood/urine[MESH] |Potassium/urine[MESH] |Urinary Calculi/drug therapy[MESH]The interactions of thiazide diuretics with parathyroid hormone and vi(epmc).pdf DeepDyve Pubget Overpricing