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10.1021/acs.orglett.5c04718

http://scihub22266oqcxt.onion/10.1021/acs.orglett.5c04718
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41391011!?!41391011

suck abstract from ncbi

pmid41391011      Org+Lett 2025 ; ? (?): ?
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  • Copper-Catalyzed Stereoselective Synthesis of Fluorinated 1,3-Dienes via Sequential Iodine-Fluorine Elimination #MMPMID41391011
  • Zhao L; Liu C; Zhang J; Li J; Li C; Zeng X
  • Org Lett 2025[Dec]; ? (?): ? PMID41391011show ga
  • We report a copper-catalyzed stereoselective synthesis of fluorinated 1,3-dienes from unactivated alkenes via base-promoted sequential iodine-fluorine elimination. This protocol leverages commercially available polyfluoroalkyl iodides and beta,gamma-unsaturated amides to deliver structurally diverse fluoro-dienes with excellent selectivity and broad functional group tolerance, including complex natural product derivatives. This method provides efficient access to previously challenging fluorinated conjugated systems, offering a versatile platform for fluorine-containing molecular design in pharmaceuticals and materials.
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