Copper-Catalyzed Stereoselective Synthesis of Fluorinated 1,3-Dienes via Sequential Iodine-Fluorine Elimination #MMPMID41391011
Zhao L; Liu C; Zhang J; Li J; Li C; Zeng X
Org Lett 2025[Dec]; ? (?): ? PMID41391011show ga
We report a copper-catalyzed stereoselective synthesis of fluorinated 1,3-dienes from unactivated alkenes via base-promoted sequential iodine-fluorine elimination. This protocol leverages commercially available polyfluoroalkyl iodides and beta,gamma-unsaturated amides to deliver structurally diverse fluoro-dienes with excellent selectivity and broad functional group tolerance, including complex natural product derivatives. This method provides efficient access to previously challenging fluorinated conjugated systems, offering a versatile platform for fluorine-containing molecular design in pharmaceuticals and materials.