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10.1038/s41467-025-66540-y http://scihub22266oqcxt.onion/10.1038/s41467-025-66540-y 41390763!?!41390763 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41390763&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Commun 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41390763|t=2025. HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing |pdf=|usr=}}{{41390763}} gab.com Text HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41390763 #FOAvip Sialic acid-containing glycans (sialoglycans) on pathological cells interact with Siglecs, glyco-immune checkpoint receptors expressed on myeloid cells, suppressing the cytotoxic functions of these immune cells. Using targeted glycomic analyses and gene editing, we show that HIV infection reprograms the glycosylation machinery of infected cells to increase the expression of the sialoglycan ligands for Siglec-3, -7, and -9. These ligands engage Siglecs on myeloid cells, impairing their ability to target HIV-infected cells. Selective disruption of these interactions using 10-1074-SiaD, an HIV-specific antibody conjugated to sialidase, an enzyme that removes sialic acids, significantly enhances monocyte- and neutrophil-mediated killing of HIV-infected cells in autologous assays. Treatment with 10-1074-SiaD in female humanized mice infected with HIV reduces viral load and decreases inflammation. These findings reveal an immune evasion mechanism exploited by HIV to evade myeloid cell immune surveillance and highlight the potential of targeting sialoglycan-Siglec interactions to improve immune clearance of HIV-infected cells. Twit Text FOAVip HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41390763 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41390763 #FOAvip English Wikipedia <ref>{{Cite pmid|41390763}}</ref> HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing #MMPMID41390763 Singh S; Islam SMS; Liu R; Adeniji OS; Simons LM; Saini P; Tateno H; Danesh A; Denton PW; Giron LB; Jones RB; Hultquist JF; Xiao H; Abdel-Mohsen M Nat Commun 2025[Dec]; ? (?): ? PMID41390763show ga Sialic acid-containing glycans (sialoglycans) on pathological cells interact with Siglecs, glyco-immune checkpoint receptors expressed on myeloid cells, suppressing the cytotoxic functions of these immune cells. Using targeted glycomic analyses and gene editing, we show that HIV infection reprograms the glycosylation machinery of infected cells to increase the expression of the sialoglycan ligands for Siglec-3, -7, and -9. These ligands engage Siglecs on myeloid cells, impairing their ability to target HIV-infected cells. Selective disruption of these interactions using 10-1074-SiaD, an HIV-specific antibody conjugated to sialidase, an enzyme that removes sialic acids, significantly enhances monocyte- and neutrophil-mediated killing of HIV-infected cells in autologous assays. Treatment with 10-1074-SiaD in female humanized mice infected with HIV reduces viral load and decreases inflammation. These findings reveal an immune evasion mechanism exploited by HIV to evade myeloid cell immune surveillance and highlight the potential of targeting sialoglycan-Siglec interactions to improve immune clearance of HIV-infected cells. ?HIV-induced sialoglycans on infected CD4+ T cells promote immune evasi(epmc).pdf DeepDyve Pubget Overpricing