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10.1038/s41598-025-32403-1 http://scihub22266oqcxt.onion/10.1038/s41598-025-32403-1 41390575!?!41390575 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41390575&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41390575|t=2025. The RNA-binding protein CPEB1 marks healthy adult beta cells in mice but is dispensable for beta cell identity and function |pdf=|usr=}}{{41390575}} gab.com Text The RNA-binding protein CPEB1 marks healthy adult beta cells in mice but is dispensable for beta cell identity and function JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=41390575 #FOAvip RNA binding proteins (RBPs) are increasingly being recognized as important regulators of pancreatic beta cells' identity and function. We identified the poly-A binding RBP, CPEB1, as a potential new regulator linked to beta cell failure in diabetes based on its enrichment in mature, healthy adult beta cells and its sharp decrease in beta cells in type 1 diabetes (T1D) and type 2 diabetes (T2D). While CPEB1 is known to regulate an extensive range of biological processes, and its involvement in regulating genes involved in insulin signaling and apoptosis in the liver has been reported, CPEB1 function in beta cells is unknown. Here, we have used two independent genetic mouse models, namely beta cell-specific and whole body Cpeb1 deletions, to assess the role of CPEB1 in beta cells. We show that CPEB1 is dispensable for beta cell function and identity. Using bulk RNA sequencing on islets of both models, we also show that CPEB1 regulates markedly different sets of genes between islets of male and female mice, both at the transcriptional and at the polyadenylation levels. Twit Text FOAVip The RNA-binding protein CPEB1 marks healthy adult beta cells in mice but is dispensable for beta cell identity and function ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=41390575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41390575 #FOAvip English Wikipedia <ref>{{Cite pmid|41390575}}</ref> The RNA-binding protein CPEB1 marks healthy adult beta cells in mice but is dispensable for beta cell identity and function #MMPMID41390575 Nimkulrat SD; Wagner MR; Waters BJ; Pintozzi NG; Mendoza Niemes MDC; Sethna CR; Jayaraaman H; Blum B Sci Rep 2025[Dec]; ? (?): ? PMID41390575show ga RNA binding proteins (RBPs) are increasingly being recognized as important regulators of pancreatic beta cells' identity and function. We identified the poly-A binding RBP, CPEB1, as a potential new regulator linked to beta cell failure in diabetes based on its enrichment in mature, healthy adult beta cells and its sharp decrease in beta cells in type 1 diabetes (T1D) and type 2 diabetes (T2D). While CPEB1 is known to regulate an extensive range of biological processes, and its involvement in regulating genes involved in insulin signaling and apoptosis in the liver has been reported, CPEB1 function in beta cells is unknown. Here, we have used two independent genetic mouse models, namely beta cell-specific and whole body Cpeb1 deletions, to assess the role of CPEB1 in beta cells. We show that CPEB1 is dispensable for beta cell function and identity. Using bulk RNA sequencing on islets of both models, we also show that CPEB1 regulates markedly different sets of genes between islets of male and female mice, both at the transcriptional and at the polyadenylation levels. ?The RNA-binding protein CPEB1 marks healthy adult beta cells in mice b(epmc).pdf DeepDyve Pubget Overpricing