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10.1038/s41467-025-67022-x http://scihub22266oqcxt.onion/10.1038/s41467-025-67022-x 41390499!?!41390499 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41390499&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Commun 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41390499|t=2025. Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance |pdf=|usr=}}{{41390499}} gab.com Text Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41390499 #FOAvip Candidozyma auris is an emerging multidrug-resistant fungal pathogen that poses a major public-health challenge owing to high mortality and the limited efficacy of current therapies. Echinocandins, which inhibit beta-glucan synthesis, are first-line therapy for invasive C. auris infection; however, resistance to this class is rising, underscoring the urgent need for new antifungal targets. Here we show that enzymes in the trehalose-biosynthetic pathway regulate stress responses, antifungal resistance/tolerance and virulence in C. auris. The tps2Delta strain displays heightened susceptibility to echinocandins, whereas tps1Delta and tps1Delta tps2Delta strains show resistance and tolerance comparable to wild type (WT). Mechanistically, the tps2Delta strain accumulates trehalose 6-phosphate (T6P), which inhibits hexokinase activity and reduces the flux of glucose 6-phosphate (G6P) into the chitin biosynthesis pathway, leading to substantially decreased cell wall chitin. During echinocandin exposure, the tps2Delta strain fails to compensate for reduced beta-glucan with increased chitin, thereby rendering it highly susceptible to these drugs. In a systemic mouse infection model, deletion of the TPS2 gene results in lower tissue fungal burdens after treatment with caspofungin. Together, these findings identify Tps2 as a potential therapeutic target that can potentiate echinocandin efficacy in C. auris via a distinct mechanism of action. Twit Text FOAVip Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41390499 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41390499 #FOAvip English Wikipedia <ref>{{Cite pmid|41390499}}</ref> Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance #MMPMID41390499 Zhu Q; Van de Velde S; Wijnants S; Carolus H; Jacobs S; Sofras D; Vandecruys P; Van Goethem O; Feil R; Vergauwen R; Van Genechten W; Van den Ende W; Rybak JM; Himmelreich U; Lunn JE; Van Dijck P Nat Commun 2025[Dec]; ? (?): ? PMID41390499show ga Candidozyma auris is an emerging multidrug-resistant fungal pathogen that poses a major public-health challenge owing to high mortality and the limited efficacy of current therapies. Echinocandins, which inhibit beta-glucan synthesis, are first-line therapy for invasive C. auris infection; however, resistance to this class is rising, underscoring the urgent need for new antifungal targets. Here we show that enzymes in the trehalose-biosynthetic pathway regulate stress responses, antifungal resistance/tolerance and virulence in C. auris. The tps2Delta strain displays heightened susceptibility to echinocandins, whereas tps1Delta and tps1Delta tps2Delta strains show resistance and tolerance comparable to wild type (WT). Mechanistically, the tps2Delta strain accumulates trehalose 6-phosphate (T6P), which inhibits hexokinase activity and reduces the flux of glucose 6-phosphate (G6P) into the chitin biosynthesis pathway, leading to substantially decreased cell wall chitin. During echinocandin exposure, the tps2Delta strain fails to compensate for reduced beta-glucan with increased chitin, thereby rendering it highly susceptible to these drugs. In a systemic mouse infection model, deletion of the TPS2 gene results in lower tissue fungal burdens after treatment with caspofungin. Together, these findings identify Tps2 as a potential therapeutic target that can potentiate echinocandin efficacy in C. auris via a distinct mechanism of action. ?Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in (epmc).pdf DeepDyve Pubget Overpricing