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10.1152/ajpregu.00219.2025 http://scihub22266oqcxt.onion/10.1152/ajpregu.00219.2025 41389012!?!41389012 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41389012&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Am+J+Physiol+Regul+Integr+Comp+Physiol 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41389012|t=2025. Acute Transcutaneous Cervical but not Auricular Vagus Nerve Stimulation Increases Alpha Wave Brain Activity and Lowers Arterial Blood Pressure |pdf=|usr=}}{{41389012}} gab.com Text Acute Transcutaneous Cervical but not Auricular Vagus Nerve Stimulation Increases Alpha Wave Brain Activity and Lowers Arterial Blood Pressure JO: Am J Physiol Regul Integr Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=41389012 #FOAvip Non-invasive vagus nerve stimulation (VNS) devices promise stress-relief through increased parasympathetic activity and a more relaxed mental state, associated with heightened alpha wave electroencephalogram (EEG) activity. The cervical vagus nerve (CVN) contains 5-6-times more Abeta-fibers than the auricular branch of the vagus nerve (ABVN). Additionally, the CVN contains afferent and efferent fibers while the ABVN is a purely afferent nerve. We hypothesized that hemodynamic, autonomic, and cerebral responses to cervical VNS are more pronounced than those to auricular VNS. Young healthy adults were randomized into a time control (n=10), a bilateral cervical VNS (n=9, 41 Hz, 100 mus, <40 mA), and two unilateral auricular VNS (10 Hz, 300 mus, 2-3 mA) groups with electrodes at the cymba conchae (n=7) or tragus (n=9) of the right ear. Systolic blood pressure (SBP) decreased only during cervical VNS (baseline: 134+/-15 mmHg vs. VNS: 120+/-16 mmHg, means+/-SD, n=9, P<0.05) which was associated with decreased low frequency (LF) SBP variability (baseline: 17.1+/-9.1 mmHg(2) vs. VNS: 7.8+/-9.1 mmHg(2), means+/-SD, n=9, P<0.05). Cervical but not auricular VNS was followed by increased alpha wave activity (baseline: 6.2+/-1.8 muV vs. VNS: 7.7+/-1.7 muV, means+/-SD, n=9, P<0.05) recorded from the FP1 EEG electrode position. In conclusion, the hemodynamic, autonomic, and EEG responses to acute bilateral cervical VNS are more pronounced than those of unilateral auricular VNS, potentially, because the CVN contains 5-6-times more Abeta-fibers than the ABVN. Reduced SBP and LF SBP variability together with increased EEG alpha wave activity may indicate a more relaxed mental state during cervical VNS. Twit Text FOAVip Acute Transcutaneous Cervical but not Auricular Vagus Nerve Stimulation Increases Alpha Wave Brain Activity and Lowers Arterial Blood Pressure ????Am J Physiol Regul Integr Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=41389012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41389012 #FOAvip English Wikipedia <ref>{{Cite pmid|41389012}}</ref> Acute Transcutaneous Cervical but not Auricular Vagus Nerve Stimulation Increases Alpha Wave Brain Activity and Lowers Arterial Blood Pressure #MMPMID41389012 Ahmed R; Coello A; Pillutla AS; Telwar G; Stauss HM Am J Physiol Regul Integr Comp Physiol 2025[Dec]; ? (?): ? PMID41389012show ga Non-invasive vagus nerve stimulation (VNS) devices promise stress-relief through increased parasympathetic activity and a more relaxed mental state, associated with heightened alpha wave electroencephalogram (EEG) activity. The cervical vagus nerve (CVN) contains 5-6-times more Abeta-fibers than the auricular branch of the vagus nerve (ABVN). Additionally, the CVN contains afferent and efferent fibers while the ABVN is a purely afferent nerve. We hypothesized that hemodynamic, autonomic, and cerebral responses to cervical VNS are more pronounced than those to auricular VNS. Young healthy adults were randomized into a time control (n=10), a bilateral cervical VNS (n=9, 41 Hz, 100 mus, <40 mA), and two unilateral auricular VNS (10 Hz, 300 mus, 2-3 mA) groups with electrodes at the cymba conchae (n=7) or tragus (n=9) of the right ear. Systolic blood pressure (SBP) decreased only during cervical VNS (baseline: 134+/-15 mmHg vs. VNS: 120+/-16 mmHg, means+/-SD, n=9, P<0.05) which was associated with decreased low frequency (LF) SBP variability (baseline: 17.1+/-9.1 mmHg(2) vs. VNS: 7.8+/-9.1 mmHg(2), means+/-SD, n=9, P<0.05). Cervical but not auricular VNS was followed by increased alpha wave activity (baseline: 6.2+/-1.8 muV vs. VNS: 7.7+/-1.7 muV, means+/-SD, n=9, P<0.05) recorded from the FP1 EEG electrode position. In conclusion, the hemodynamic, autonomic, and EEG responses to acute bilateral cervical VNS are more pronounced than those of unilateral auricular VNS, potentially, because the CVN contains 5-6-times more Abeta-fibers than the ABVN. Reduced SBP and LF SBP variability together with increased EEG alpha wave activity may indicate a more relaxed mental state during cervical VNS. ?Acute Transcutaneous Cervical but not Auricular Vagus Nerve Stimulatio(epmc).pdf DeepDyve Pubget Overpricing