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10.1186/s12876-025-04555-x http://scihub22266oqcxt.onion/10.1186/s12876-025-04555-x 41382010!?!41382010 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41382010&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       BMC+Gastroenterol 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41382010|t=2025. The causal relationship between body mass index and perianal abscess: a Mendelian randomization study |pdf=|usr=}}{{41382010}} gab.com Text The causal relationship between body mass index and perianal abscess: a Mendelian randomization study JO: BMC Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=41382010 #FOAvip BACKGROUND: Observational studies suggest an association between elevated body mass index (BMI) and perianal abscess risk, but residual confounding and reverse causality limit causal inference. Mendelian randomization (MR) offers a robust approach to assess causality by leveraging genetic variants as instrumental variables. This study aimed to evaluate the causal relationship between BMI and perianal abscess using a MR framework. METHODS: We analyzed European-ancestry genome-wide association study (GWAS) data for BMI (n = 359,983) and perianal abscess (1,287 cases/182,423 controls). A total of 364 independent SNPs associated with BMI at genome-wide significance (P < 5 x 10(-)(8)) were selected as instrumental variables, with stringent linkage disequilibrium clumping (r(2) < 0.01, clumping distance > 10,000 kb). Causal estimates were derived using inverse-variance weighted (IVW), MR-Egger, weighted median, and MR-PRESSO methods. Multivariable MR (MVMR) adjusted for lipid metabolism disorders and insulin resistance. Sensitivity analyses assessed pleiotropy, heterogeneity, and instrument strength. RESULTS: Genetically predicted higher BMI was causally associated with an increased risk of perianal abscess (IVW: OR = 1.94, 95%CI: 1.46-2.68, P = 3.8 x 10(-)(6)). Consistency across methods (MR-Egger: OR = 2.80; weighted median: OR = 2.30) and MVMR adjustment (OR = 1.47, 95%CI: 1.12-1.93) supported robustness. No evidence of directional pleiotropy (MR-Egger intercept P = 0.30) or heterogeneity (I(2) = 7.6%; MR-PRESSO global test P = 0.148) was observed. Instrument strength was sufficient (mean F-statistic = 37.75), mitigating weak instrument bias. CONCLUSION: This MR study provides robust genetic evidence supporting BMI as a causal risk factor for perianal abscess. The findings highlight obesity management as a potential preventive strategy, though multifactorial mechanisms warrant further investigation. Twit Text FOAVip The causal relationship between body mass index and perianal abscess: a Mendelian randomization study ????BMC Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=41382010 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41382010 #FOAvip English Wikipedia <ref>{{Cite pmid|41382010}}</ref> The causal relationship between body mass index and perianal abscess: a Mendelian randomization study #MMPMID41382010 Wu L; Wu H; Li XY; Zhen YH; Li HY BMC Gastroenterol 2025[Dec]; ? (?): ? PMID41382010show ga BACKGROUND: Observational studies suggest an association between elevated body mass index (BMI) and perianal abscess risk, but residual confounding and reverse causality limit causal inference. Mendelian randomization (MR) offers a robust approach to assess causality by leveraging genetic variants as instrumental variables. This study aimed to evaluate the causal relationship between BMI and perianal abscess using a MR framework. METHODS: We analyzed European-ancestry genome-wide association study (GWAS) data for BMI (n = 359,983) and perianal abscess (1,287 cases/182,423 controls). A total of 364 independent SNPs associated with BMI at genome-wide significance (P < 5 x 10(-)(8)) were selected as instrumental variables, with stringent linkage disequilibrium clumping (r(2) < 0.01, clumping distance > 10,000 kb). Causal estimates were derived using inverse-variance weighted (IVW), MR-Egger, weighted median, and MR-PRESSO methods. Multivariable MR (MVMR) adjusted for lipid metabolism disorders and insulin resistance. Sensitivity analyses assessed pleiotropy, heterogeneity, and instrument strength. RESULTS: Genetically predicted higher BMI was causally associated with an increased risk of perianal abscess (IVW: OR = 1.94, 95%CI: 1.46-2.68, P = 3.8 x 10(-)(6)). Consistency across methods (MR-Egger: OR = 2.80; weighted median: OR = 2.30) and MVMR adjustment (OR = 1.47, 95%CI: 1.12-1.93) supported robustness. No evidence of directional pleiotropy (MR-Egger intercept P = 0.30) or heterogeneity (I(2) = 7.6%; MR-PRESSO global test P = 0.148) was observed. Instrument strength was sufficient (mean F-statistic = 37.75), mitigating weak instrument bias. CONCLUSION: This MR study provides robust genetic evidence supporting BMI as a causal risk factor for perianal abscess. The findings highlight obesity management as a potential preventive strategy, though multifactorial mechanisms warrant further investigation. ?The causal relationship between body mass index and perianal abscess: (epmc).pdf DeepDyve Pubget Overpricing