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10.1038/s41467-025-67356-6 http://scihub22266oqcxt.onion/10.1038/s41467-025-67356-6 41381565!?!41381565       Nat+Commun 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41381565|t=2025. A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma |pdf=|usr=}}{{41381565}} gab.com Text A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41381565 #FOAvip Penile squamous cell carcinoma (PSCC) is a rare, aggressive malignancy, with HPV driving approximately 50% of cases and correlating with improved outcomes. In this study, we perform single-cell RNA sequencing on tumor microenvironment (TME) cells from 23 treatment-naive PSCC patients, including 11 cases reported previously, and validate our findings in a larger cohort of 85 patients. Our analysis reveals significant immune cell infiltration in PSCC, with HPV(+) tumors exhibiting elevated levels of tumor-infiltrating B cells, plasma cells, tertiary lymphoid structures, and IgA secretion. A subset of malignant epithelial cells in HPV(+) PSCC express the polymeric IgA receptor (PIGR), facilitating IgA transcytosis and inducing anti-tumor responses. Functional studies show that PIGR overexpression promotes tumor apoptosis and enhances immune responses, with these effects diminish in IgA-deficient mice. Elevated IgA and PIGR expression correlate with improved survival. These findings provide a single-cell atlas of the PSCC TME, highlighting the B cell-IgA-PIGR axis as a pivotal driver of antitumor immunity and clinical outcomes in HPV(+) PSCC. Twit Text FOAVip A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=41381565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41381565 #FOAvip English Wikipedia <ref>{{Cite pmid|41381565}}</ref> A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma #MMPMID41381565 Tao T; Zhu L; Shen D; Zhang J; Zhang P; Gu Z; Cao D; Xiao J; Pan W Nat Commun 2025[Dec]; ? (?): ? PMID41381565show ga Penile squamous cell carcinoma (PSCC) is a rare, aggressive malignancy, with HPV driving approximately 50% of cases and correlating with improved outcomes. In this study, we perform single-cell RNA sequencing on tumor microenvironment (TME) cells from 23 treatment-naive PSCC patients, including 11 cases reported previously, and validate our findings in a larger cohort of 85 patients. Our analysis reveals significant immune cell infiltration in PSCC, with HPV(+) tumors exhibiting elevated levels of tumor-infiltrating B cells, plasma cells, tertiary lymphoid structures, and IgA secretion. A subset of malignant epithelial cells in HPV(+) PSCC express the polymeric IgA receptor (PIGR), facilitating IgA transcytosis and inducing anti-tumor responses. Functional studies show that PIGR overexpression promotes tumor apoptosis and enhances immune responses, with these effects diminish in IgA-deficient mice. Elevated IgA and PIGR expression correlate with improved survival. These findings provide a single-cell atlas of the PSCC TME, highlighting the B cell-IgA-PIGR axis as a pivotal driver of antitumor immunity and clinical outcomes in HPV(+) PSCC. ?A B cell-IgA-epithelial axis enhances antitumor immunity and improves (epmc).pdf DeepDyve Pubget Overpricing