Cation exchange reaction in Bi(2)S(3) nanorods enables the one-step fabrication of copper-64 nanoparticulate molecular PET imaging agents with ultrahigh radiolabel stability #MMPMID41370037
Milanova V; Tieu W; Asp J; Akkermans S; Keller M; Winter M; Skinner W; Thierry B
J Mater Chem B 2025[Dec]; ? (?): ? PMID41370037show ga
New molecular positron emission tomography (PET) imaging agents with high radiolabel stability are needed to expand the use of modality in oncology. Due to the radioactive decay of radiometals suitable for PET imaging, the development of a rapid, efficient, and reproducible method is also critical. We present here a novel "shake and use" approach for the production of copper-64 ((64)Cu) nanoparticle-based PET imaging agents based on a cation exchange reaction in metal chalcogenides. (64)Cu:bismuth sulfide ((64)Cu:Bi(2)S(3)) nanorods could be prepared within 10 min and under ambient conditions, with an extremely high radiochemical yield of almost 100% and an outstanding radiolabel stability of 99% at 24 h in serum at 37 degrees C. Remarkably, the (64)Cu cation exchange reaction can be performed with Cetuximab-functionalized Bi(2)S(3) nanorods without impacting the binding performance. The simplicity of the method and excellent radiolabeling and radiolabel stability afforded by the cation exchange reaction of (64)Cu in Bi(2)S(3) suggest the feasibility of "point-of-need" radiolabeling and warrant further investigation.
J+Mater+Chem+B 2025 ; ? (?): ?
