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Multimodal imaging predictors of recurrence after photodynamic therapy in chronic central serous chorioretinopathy #MMPMID41369849
Urvasizoglu S; Topcu H; Tuygun Alkin Z
Int Ophthalmol 2025[Dec]; 46 (1): 13 PMID41369849show ga
PURPOSE: To evaluate the correlation between spectral-domain optical coherence tomography (SD-OCT), fundus fluorescein angiography (FFA), and indocyanine green angiography (ICGA) findings and recurrence following photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC). METHODS: We retrospectively reviewed medical records of 68 eyes from 68 patients diagnosed with cCSC and treated with PDT. Demographic data, duration of symptoms before treatment, baseline best-corrected visual acuity (BCVA), and multimodal imaging features (SD-OCT, FFA, ICGA) were analyzed. Patients were followed up to 24 months post-PDT for recurrence. RESULTS: The mean age was 48.1 +/- 10.4 years; 76.5% were male. Recurrence was observed in 19 patients (27.9%). Longer symptom duration before PDT (20.9 vs 13.3 months, p = 0.001), presence of non-shallow PED on SD-OCT (68.4% vs 38.8%, p = 0.02), and RPE changes on fundoscopy (94.7% vs 71.4%, p = 0.03) were significantly associated with recurrence. No significant correlation was found with FFA or ICGA findings. CONCLUSION: Longer symptom duration and certain SD-OCT and fundus features may predict recurrence after PDT in cCSC. Recognizing these predictors could help guide earlier treatment decisions.
Int+Ophthalmol 2025 ; 46 (1): 13
