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10.1007/s00223-025-01463-w http://scihub22266oqcxt.onion/10.1007/s00223-025-01463-w 41361655!12686089!41361655     free     free     free       Calcif+Tissue+Int 2025 ; 116 (1): 149 Nephropedia Template TP {{tp|p=41361655|t=2025. Dietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies |pdf=|usr=}}{{41361655}} gab.com Text Dietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies JO: Calcif Tissue Int http://www.kidney.de/pget.php?&tw=1&pmid=41361655 #FOAvip Studies evaluating habitual dietary copper intake and bone mineral density have garnered significant interest due to copper's indispensable role in collagen cross-linking and osteogenesis. These investigations, which employ dietary assessment tools alongside DXA measurements of skeletal sites, have nonetheless yielded heterogeneous results regarding the impact of copper consumption on bone health. Consequently, elucidating the nature and magnitude of this association is of paramount importance for both nutritional epidemiology and osteoporosis prevention. The review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42024617075). Electronic literature searches were performed up to February 2025 in EMBASE, PubMed, OVID, Scopus, and Web of Science to identify observational studies assessing dietary copper intake and DXA-measured BMD, and study quality was appraised using the Newcastle-Ottawa Scale. Data were pooled via a generic inverse-variance random-effects model, with heterogeneity assessed by the Q test and I(2) statistic. A random-effects meta-analysis of three studies (n = 9059) found that higher dietary copper intake was associated with a modest but significant increase in lumbar spine BMD (MD 0.02 g/cm(2); 95% CI 0.00-0.04; p = 0.04; I(2) = 36%), whereas a separate meta-analysis of four studies (n = 14,345) for hip BMD showed a similar MD of 0.02 g/cm(2) that did not reach significance (95% CI - 0.00-0.04; p = 0.07; I(2) = 74%). Higher dietary copper intake is modestly associated with increased lumbar spine BMD, while evidence for hip BMD remains inconclusive, underscoring copper's potential role in osteoporosis prevention. Twit Text FOAVip Dietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies ????Calcif Tissue Int http://www.kidney.de/pget.php?&tw=1&pmid=41361655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41361655 #FOAvip English Wikipedia <ref>{{Cite pmid|41361655}}</ref> Dietary Copper Intake and Bone Health: A Systematic Review and Meta-Analysis of Observational Studies #MMPMID41361655 Gutierrez-Guerra MA; Puerto-Parejo LM; Pastor-Ramon E; Pedrera-Canal M; Vera V; Pedrera-Zamorano JD; Lavado-Garcia JM; Lopez-Espuela F; Roncero-Martin R; Fabregat-Fernandez J; Moran JM Calcif Tissue Int 2025[Dec]; 116 (1): 149 PMID41361655show ga Studies evaluating habitual dietary copper intake and bone mineral density have garnered significant interest due to copper's indispensable role in collagen cross-linking and osteogenesis. These investigations, which employ dietary assessment tools alongside DXA measurements of skeletal sites, have nonetheless yielded heterogeneous results regarding the impact of copper consumption on bone health. Consequently, elucidating the nature and magnitude of this association is of paramount importance for both nutritional epidemiology and osteoporosis prevention. The review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42024617075). Electronic literature searches were performed up to February 2025 in EMBASE, PubMed, OVID, Scopus, and Web of Science to identify observational studies assessing dietary copper intake and DXA-measured BMD, and study quality was appraised using the Newcastle-Ottawa Scale. Data were pooled via a generic inverse-variance random-effects model, with heterogeneity assessed by the Q test and I(2) statistic. A random-effects meta-analysis of three studies (n = 9059) found that higher dietary copper intake was associated with a modest but significant increase in lumbar spine BMD (MD 0.02 g/cm(2); 95% CI 0.00-0.04; p = 0.04; I(2) = 36%), whereas a separate meta-analysis of four studies (n = 14,345) for hip BMD showed a similar MD of 0.02 g/cm(2) that did not reach significance (95% CI - 0.00-0.04; p = 0.07; I(2) = 74%). Higher dietary copper intake is modestly associated with increased lumbar spine BMD, while evidence for hip BMD remains inconclusive, underscoring copper's potential role in osteoporosis prevention. |*Bone Density/drug effects/physiology[MESH] |*Bone and Bones/drug effects[MESH] |*Copper/administration & dosage/pharmacology[MESH] |*Diet[MESH] |Female[MESH] |Humans[MESH] |Observational Studies as Topic[MESH]Dietary Copper Intake and Bone Health: A Systematic Review and Meta-An(epmc).pdf DeepDyve Pubget Overpricing