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10.1111/aas.70161 http://scihub22266oqcxt.onion/10.1111/aas.70161 41359999!12685386!41359999     free     free     free       Acta+Anaesthesiol+Scand 2026 ; 70 (1): e70161 Nephropedia Template TP {{tp|p=41359999|t=2026. Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi-Centre Cohort Study of 1014 Patients |pdf=|usr=}}{{41359999}} gab.com Text Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi-Centre Cohort Study of 1014 Patients JO: Acta Anaesthesiol Scand http://www.kidney.de/pget.php?&tw=1&pmid=41359999 #FOAvip BACKGROUND: Many patients undergoing prehospital anaesthesia may be at risk of inadequate cerebral oxygenation due to underlying conditions or adverse events like hypotension or hypoxia. This study examined whether a decrease in regional cerebral oxygen saturation (rSO(2)) measured with near-infrared spectroscopy (NIRS) during prehospital anaesthesia associates with worse outcomes. METHODS: We conducted a prospective, observational study including adult patients anaesthetised by six prehospital critical care teams. A relative cerebral desaturation event (rCDE) was defined as a >/= 10% decrease in rSO(2) for >/= 5 min from baseline. An absolute cerebral desaturation event (aCDE) was defined as rSO(2) < 60% during anaesthesia or lower than baseline if already < 60%. The primary outcome was favourable functional outcome (modified Rankin Scale </= 2) at 30 days and secondary outcomes included 30-day survival, 1-year functional outcome, and 1-year survival. RESULTS: Among 1014 patients, 199 experienced an rCDE, with 125 (63%) having supraphysiological baseline. rCDE was not associated with outcomes. Of 182 patients with aCDE, 30-day favourable outcomes were not significantly different (30% vs. 36%, p = 0.14, adjusted OR 0.92, 95% confidence interval 0.62-1.34). However, aCDE was associated with lower 30-day survival (46% vs. 58%, p = 0.006) and less favourable 1-year outcomes (31% vs. 41%, p = 0.043). Adjusted analyses showed no significant associations. CONCLUSION: An rCDE was not associated with worse functional outcomes. While aCDEs were linked to unfavourable outcomes in unadjusted analyses, these associations were not significant after adjustment, highlighting the complexity of interpreting NIRS in heterogeneous populations. Condition-specific studies are needed to clarify its role. EDITORIAL COMMENT: Cerebral oxygen delivery may be jeopardized in critically ill patients undergoing prehospital anaesthesia. This study assessed near-infrared spectroscopy on the forehead in a large number of cases requiring general anaesthesia and subsequent transportation to hospital by helicopter. In unadjusted analysis, patients with an at least 10% decline in forehead saturation had higher survival and better functional outcome, whereas those with a forehead saturation below 60% had lower survival and worse functional outcome. Upon multivariable regression, age, patient category, systemic oxygen saturation and Glasgow Coma Scale score were independent predictors of worse outcomes, but forehead oxygen saturation was not. NIRS-measured forehead saturation decrease appears to associate in a complex fashion with more traditional predictors of patient outcomes. Whether effects of resuscitation interventions like these can be assessed reliably by NIRS is not yet well understood. TRIAL REGISTRATION: The study protocol was published beforehand on clinicaltrials.gov (NCT04144803) on 7th October 2019. Twit Text FOAVip Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi-Centre Cohort Study of 1014 Patients ????Acta Anaesthesiol Scand http://www.kidney.de/pget.php?&tw=1&pmid=41359999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41359999 #FOAvip English Wikipedia <ref>{{Cite pmid|41359999}}</ref> Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi-Centre Cohort Study of 1014 Patients #MMPMID41359999 Saviluoto A; Raatiniemi L; Makela S; Toivonen T; Setala P; Kirves H; Tommila M; Toivonen P; Tukia S; Nurmi J Acta Anaesthesiol Scand 2026[Jan]; 70 (1): e70161 PMID41359999show ga BACKGROUND: Many patients undergoing prehospital anaesthesia may be at risk of inadequate cerebral oxygenation due to underlying conditions or adverse events like hypotension or hypoxia. This study examined whether a decrease in regional cerebral oxygen saturation (rSO(2)) measured with near-infrared spectroscopy (NIRS) during prehospital anaesthesia associates with worse outcomes. METHODS: We conducted a prospective, observational study including adult patients anaesthetised by six prehospital critical care teams. A relative cerebral desaturation event (rCDE) was defined as a >/= 10% decrease in rSO(2) for >/= 5 min from baseline. An absolute cerebral desaturation event (aCDE) was defined as rSO(2) < 60% during anaesthesia or lower than baseline if already < 60%. The primary outcome was favourable functional outcome (modified Rankin Scale |*Anesthesia[MESH] |*Brain/metabolism[MESH] |*Emergency Medical Services[MESH] |*Oxygen Saturation[MESH] |*Oxygen/metabolism[MESH] |Adult[MESH] |Aged[MESH] |Cerebrovascular Circulation[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |Spectroscopy, Near-Infrared[MESH]Association of Cerebral Oxygenation During Prehospital Anaesthesia and(epmc).pdf DeepDyve Pubget Overpricing